The Electrochemical Approach towards Proton Coupled Electron Transfer Pathways for Oxidation of Thymine in Water

The work describes the use of cyclic voltammetry to investigate the proton coupled electron transfer (PCET) pathways for oxidation of thymine in water. Biologically important compounds like DNA bases, and amino acids showed irreversible behavior when oxidized electrochemically. The reversible redox...

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Bibliographic Details
Published in:ECS transactions 2013-10, Vol.53 (16), p.17-25
Main Authors: Soomro, Muhammad Tahir, Grampp, Guenter, Nguyen, Truong Xuan, Ismail, Iqbal Mohammad
Format: Article
Language:English
Online Access:Get full text
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Summary:The work describes the use of cyclic voltammetry to investigate the proton coupled electron transfer (PCET) pathways for oxidation of thymine in water. Biologically important compounds like DNA bases, and amino acids showed irreversible behavior when oxidized electrochemically. The reversible redox potentials for such systems (say, irreversible electrochcemical systems) were estimated by analyzing the cyclic voltammograms recorded at different scan rates. The approach presents here is relatively simple and easy for obtaining reversible redox potential of electrochemically irreversible systems. Moreover, for the case of thymine, the obtained reversible oxidation potential also used to establish the PCET-pathways for oxidation of thymine in water.
ISSN:1938-5862
1938-6737
DOI:10.1149/05316.0017ecst