Study on effectiveness of anti-infective system using a planar transducer irradiating low-intensity ultrasound to titanium dioxide particles

Infections at the exit site of a catheter retained in a body have become a serious problem. Conversely, reactive oxygen species (ROS), which have an anti-infective effect, can be produced by ultrasound irradiation to titanium dioxide. Therefore, an anti-infective catheter system using low-intensity...

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Bibliographic Details
Published in:Japanese Journal of Applied Physics 2020-07, Vol.59 (SK), p.SKKE18
Main Authors: Tominaga, Mayu, Kaya, Akio, Ohta, Yuji, Nitta, Naotaka
Format: Article
Language:English
Subjects:
low intensity
optimal conditions
planar transducer
reactive oxygen species
temperature rise
titanium dioxide
ultrasound irradiation
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Summary:Infections at the exit site of a catheter retained in a body have become a serious problem. Conversely, reactive oxygen species (ROS), which have an anti-infective effect, can be produced by ultrasound irradiation to titanium dioxide. Therefore, an anti-infective catheter system using low-intensity focused ultrasound (LIFU) was developed. However, in daily clinical use, the attachment to the skin is not easy due to the concave shape of the transducer. To overcome this problem, the feasibility of using a planar transducer instead of the conventional concave transducer was investigated in this study. The results of the experiment using a methylene blue solution and a thin-film thermocouple revealed that the ROS production was enhanced even when a planar transducer with a lower intensity than a conventional LIFU was used. Moreover, the temperature rise due to the heating of the transducer surface was insignificant.
ISSN:0021-4922
1347-4065
DOI:10.35848/1347-4065/ab8c9c