High Density Lipoprotein Cholesterol and the Risk of Stroke in Elderly Men

High density lipoprotein (HDL) cholesterol has been inversely associated with coronary heart disease. Associations with stroke are less clear, particularly among the elderly. In this study, the authors examined the relation between HDL cholesterol levels and the risk of stroke in elderly men. Levels...

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Bibliographic Details
Published in:American journal of epidemiology 2004-07, Vol.160 (2), p.150-157
Main Authors: Curb, J. David, Abbott, Robert D., Rodriguez, Beatriz L., Masaki, Kamal H., Chen, Randi, Popper, Jordan S., Petrovitch, Helen, Ross, G. Webster, Schatz, Irwin J., Belleau, Gina C., Yano, Katsuhiko
Format: Article
Language:English
Subjects:
Abbreviation: HDL
aged
cerebrovascular accident
HDL cholesterol
high density lipoprotein
lipoproteins
men
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Summary:High density lipoprotein (HDL) cholesterol has been inversely associated with coronary heart disease. Associations with stroke are less clear, particularly among the elderly. In this study, the authors examined the relation between HDL cholesterol levels and the risk of stroke in elderly men. Levels of HDL cholesterol were measured in 2,444 Honolulu Heart Program men aged 71–93 years at the 1991–1993 examinations. The participants, who were free of prevalent stroke, coronary heart disease, and cancer at baseline, were followed to the end of 1998 for thromboembolic and hemorrhagic stroke. While HDL cholesterol was unrelated to hemorrhagic events, incidence of thromboembolic stroke declined consistently with increasing HDL cholesterol level (p = 0.003). There was a nearly threefold excess of thromboembolic stroke in men with low HDL cholesterol levels (
ISSN:0002-9262
1476-6256
DOI:10.1093/aje/kwh177