Hypercalcemia in a Case of Childhood Acute Lymphoblastic Leukemia

Severe hypercalcemia (serum calcium, 4.25–5.25 mmol/l), in association with osteolytic bone lesions, was found in a girl aged 2 yr 7 mo with common acute lymphoblastic leukemia (ALL). Hormonal studies excluded the possibility of the hypercalcemia being caused by primary hyperparathyroidism or ectopi...

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Bibliographic Details
Published in:Japanese Journal of Clinical Oncology 1987, Vol.17 (4), p.357-362
Main Authors: Todo, Shinjiro, Imashuku, Shinsaku, Inoda, Hiroshi, Yamanaka, Hirofumi, Hibi, Shigeyoshi, Tsunamoto, Kentaro, Esumi, Noriko, Fujiwara, Fumihiro, Shimizu, Yoshitaka, Morioka, Yoshihito, Sugimoto, Tohru
Format: Report
Language:English
Subjects:
Common acute lymphoblastic leukemia
Hypercalcemia
Prostaglandin E2
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Summary:Severe hypercalcemia (serum calcium, 4.25–5.25 mmol/l), in association with osteolytic bone lesions, was found in a girl aged 2 yr 7 mo with common acute lymphoblastic leukemia (ALL). Hormonal studies excluded the possibility of the hypercalcemia being caused by primary hyperparathyroidism or ectopic parathyroid hormone secretion. Increased plasma prostaglandinE2 (PGE2).J levels (130 ng/l), probably produced by leukemic cells, were considered to be one of the pathogenic mechanisms responsible for the occurrence of hypercalcemia in this patient. Both the hypercalcemia and the abnormal plasma PGE2 level returned to normal after chemotherapy.
ISSN:0368-2811
1465-3621
DOI:10.1093/oxfordjournals.jjco.a039219