Human Arterial Wall Cells Secrete Factors That are Chemotactic for Monocytes

Macrophages and arterial smooth muscle cells comprise the cellular components of the atherosclerotic plaque. The vessel wall accumulation of macrophages occurs by a process of increased circulating monocyte migration into the vessel wall. In these studies it is demonstrated that human macrophages an...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1983-08, Vol.80 (16), p.5094-5097
Main Authors: Mazzone, Theodore, Jensen, Martha, Chait, Alan
Format: Article
Language:English
Subjects:
Arteries - metabolism
Blood vessels
Cell Differentiation
Cells, Cultured
Chemotactic factors
Chemotactic Factors - metabolism
Chemotaxis
Chemotaxis, Leukocyte
Cultured cells
Fibroblasts
Humans
Kinetics
Macrophages
Macrophages - physiology
Monocytes
Monocytes - physiology
Smooth muscle
Smooth muscle myocytes
Ungulates
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Summary:Macrophages and arterial smooth muscle cells comprise the cellular components of the atherosclerotic plaque. The vessel wall accumulation of macrophages occurs by a process of increased circulating monocyte migration into the vessel wall. In these studies it is demonstrated that human macrophages and arterial smooth muscle cells in culture secrete potent chemotactic factors for freshly isolated human monocytes. In contrast, human fibroblast-conditioned medium has no chemotactic activity. The effect of macrophage-conditioned medium is a function of macrophage differentiation and can be potentiated by macrophage activation. These results suggest that secretory products of human macrophages and arterial smooth muscle cells may be important stimuli for increased monocyte migration into the vessel wall in vivo.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.80.16.5094