FACTORS REGULATING MITOSIS IN EUKARYOTIC CELLS

The orderly progression of eukaryotic cells from interphase to mitosis requires the close coordination of various nuclear and cytoplasmic events. These include the breakdown of the nuclear membrane, condensation of chromosomes, reorganization of the microtubule network, centriole duplication, format...

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Bibliographic Details
Published in:Current science (Bangalore) 1987-01, Vol.56 (2), p.55-72
Main Authors: ADLAKHA, RAMESH C., RAO, POTU N.
Format: Article
Language:English
Subjects:
Cell cycle
Chromosomes
Daughter cells
Delta cells
HeLa cells
Interphase
L cells
Mitosis
Oocytes
Phosphorylation
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Summary:The orderly progression of eukaryotic cells from interphase to mitosis requires the close coordination of various nuclear and cytoplasmic events. These include the breakdown of the nuclear membrane, condensation of chromosomes, reorganization of the microtubule network, centriole duplication, formation of the mitotic spindle and cytokinesis. Mitotic chromosome replication is an important and critical event for the proper segregation of genetic material between the two daughter cells. Although the mechanisms for the control of these events are not properly understood, several recent studies utilizing a variety of different experimental approaches suggest that the presence or absence of specific proteins or enzymatic activities may be extremely important. Our laboratory has recently demonstrated the existence of two such nonhistone protein factors, one of which is only present in mitotic cells and the other only in G1 cells. These factors seem to play an important role in the regulation of the initiation and the completion of mitosis, respectively. The properties, the physiological roles and the mechanisms by which these two factors regulate mitosis are reviewed.
ISSN:0011-3891