The nucleus acts as a ruler tailoring cell responses to spatial constraints

Single cells continuously experience and react to mechanical challenges in three-dimensional tissues. Spatial constraints in dense tissues, physical activity, and injury all impose changes in cell shape. How cells can measure shape deformations to ensure correct tissue development and homeostasis re...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) 2020-10, Vol.370 (6514), p.310-310
Main Authors:	Lomakin, A. J., Cattin, C. J., Cuvelier, D., Alraies, Z., Molina, M., Nader, G. P. F., Srivastava, N., Saez, P. J., Garcia-Arcos, J. M., Zhitnyak, I. Y., Bhargava, A., Driscoll, M. K., Welf, E. S., Fiolka, R., Petrie, R. J., De Silva, N. S., González-Granado, J. M., Manel, N., Lennon-Duménil, A. M., Müller, D. J., Piel, M.
Format:	Article
Language:	English
Subjects:	Actomyosin Actomyosin - metabolism Adaptation Adenosine Adenosine triphosphatase Animals Arachidonic acid Behavior Calcium Cancer Cell migration Cell Movement Cell size Compression Compression tests Confinement Contractility Crowding Deformation Developmental stages Diagnostic systems Embryogenesis Embryonic Development Embryonic growth stage Epigenetics Fatty acids Feedback (Response) Force measurement HeLa Cells Homeostasis Humans Immune response Immune system Life Sciences Mechanotransduction Mechanotransduction, Cellular Membranes Mice Microenvironments Myosin Myosin Heavy Chains - metabolism Neoplasm Invasiveness Neoplasms - pathology Neuroimaging Nuclear Envelope - physiology Nuclei (cytology) Phospholipase Phospholipase C Physical activity Polyunsaturated fatty acids RESEARCH ARTICLE SUMMARY Signal transduction Signaling Tissues Triphosphatase Tumors
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