Enhancing Polyethylenimine's Delivery of Plasmid DNA into Mammalian Cells

The effect of various chemical modifications of nitrogen atoms on the efficiency of polyethylenimines (PEIs) as synthetic vectors for the delivery of plasmid DNA into monkey kidney cells in vitro has been systematically investigated. The resultant structure-activity relationship has both provided me...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2002-11, Vol.99 (23), p.14640-14645
Main Authors: Thomas, Mini, Klibanov, Alexander M.
Format: Article
Language:English
Subjects:
Alkylation
Amines
Animals
Applied Biological Sciences
Biochemistry
Biological Sciences
Bromides
Cell Line
Cells
Chemistry
Chlorocebus aethiops
COS Cells
Cytotoxicity
Deoxyribonucleic acid
DNA
Genes, Synthetic
Genetic Vectors
Indicators and Reagents
Kidney cells
Kidneys
Mammals
Monkeys & apes
Physical Sciences
Plasmids
Polyethyleneimine
Protons
Solvents
Transfection
Transfection - methods
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