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Regulation of Meiotic Chromatin Loop Size by Chromosomal Position

At meiotic prophase, chromatin loops around a proteinaceous core, with the sizes of these loops varying between species. Comparison of the morphology of sequence-related inserts at different sites in transgenic mice demonstrates that loop size also varies with chromosomal geography. Similarly, chrom...

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Published in:	Proceedings of the National Academy of Sciences - PNAS 1996-04, Vol.93 (7), p.2795-2800
Main Authors:	Henry H. Q. Heng, Chamberlain, John W., Shi, Xiao-Mei, Spyropoulos, Barbara, Tsui, Lap-Chee, Moens, Peter B.
Format:	Article
Language:	English
Subjects:	Animals Chromatin Chromatin - ultrastructure Chromosomes Chromosomes - physiology Chromosomes - ultrastructure Cricetinae DNA Fishing lines Fluorescence in situ hybridization Genetics HLA-B7 Antigen - biosynthesis HLA-B7 Antigen - genetics Humans In Situ Hybridization, Fluorescence Lymphocytes - cytology Lymphocytes - physiology Lymphocytes - ultrastructure Meiosis Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Transgenic Mitosis Packaging Rats Telomeres Transgenic animals
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cited_by	cdi_FETCH-LOGICAL-c513t-8116821a53dca946fe2356628f914832cbe45ee70a9c1f0240b1ff600e48cb0c3
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container_end_page	2800
container_issue	7
container_start_page	2795
container_title	Proceedings of the National Academy of Sciences - PNAS
container_volume	93
creator	Henry H. Q. Heng Chamberlain, John W. Shi, Xiao-Mei Spyropoulos, Barbara Tsui, Lap-Chee Moens, Peter B.
description	At meiotic prophase, chromatin loops around a proteinaceous core, with the sizes of these loops varying between species. Comparison of the morphology of sequence-related inserts at different sites in transgenic mice demonstrates that loop size also varies with chromosomal geography. Similarly, chromatin loop lengths differ dramatically for interstitially and terminally located hamster telomeric sequences. Sequences, telomeric or otherwise, located at chromosome termini, closely associate with the meiotic proteinaceous core, forming shorter loops than identical interstitial sequences. Thus, we present evidence that different chromatin packaging mechanisms exist for interstitial versus terminal chromosomal regions, which act separately from those operating at the level of the DNA sequence. Chromosomal position plays the dominant role in chromatin packaging.
doi_str_mv	10.1073/pnas.93.7.2795
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source	JSTOR Archival Journals and Primary Sources Collection; PubMed Central
subjects	Animals Chromatin Chromatin - ultrastructure Chromosomes Chromosomes - physiology Chromosomes - ultrastructure Cricetinae DNA Fishing lines Fluorescence in situ hybridization Genetics HLA-B7 Antigen - biosynthesis HLA-B7 Antigen - genetics Humans In Situ Hybridization, Fluorescence Lymphocytes - cytology Lymphocytes - physiology Lymphocytes - ultrastructure Meiosis Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Transgenic Mitosis Packaging Rats Telomeres Transgenic animals
title	Regulation of Meiotic Chromatin Loop Size by Chromosomal Position
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