The Age-Related Rise of Plasma Cholesterol in Humans Is Not Caused by a Cell Removal Defect of LDL Particles: ‘In vitro’ Studies in Peripheral Mononuclear Blood Cells

In healthy subjects with a normal body mass index, total plasma cholesterol, low-density lipoprotein (LDL) cholesterol, and apoB lipoprotein levels are higher in older individuals (n = 34) than in younger subjects (n = 43). The two groups studied ranged in age from 60 to 93 years and from 17 to 30 y...

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Published in:Gerontology (Basel) 1997, Vol.43 (4), p.232-241
Main Authors: Neves, Monica Q.T.S., Carvalho, Márcia D.T., Passarelli, Marisa, Nakandakare, Edna R., Bernik, Márcia M.M.S., Quintão, Eder C.R.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aging - physiology
Apolipoproteins B - blood
Apolipoproteins B - metabolism
Biological and medical sciences
Carbon Radioisotopes
Cholesterol - blood
Cholesterol, LDL - blood
Cholesterol, LDL - genetics
Clinical Section
Fundamental and applied biological sciences. Psychology
Gene Expression
Humans
In Vitro Techniques
Leukocytes, Mononuclear - metabolism
Lipids. Glycolipids
Male
Metabolisms and neurohumoral controls
Middle Aged
Receptors, LDL - genetics
Receptors, LDL - physiology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:In healthy subjects with a normal body mass index, total plasma cholesterol, low-density lipoprotein (LDL) cholesterol, and apoB lipoprotein levels are higher in older individuals (n = 34) than in younger subjects (n = 43). The two groups studied ranged in age from 60 to 93 years and from 17 to 30 years, respectively. The cholesterol synthesis rates of peripheral mononuclear blood cells from 14 C-acetate, total and unesterified cholesterol concentrations in freshly isolated cells, and the rates of uptake of pooled donor LDL, labeled with 125 I- or 14 C-cholesteryl oleoyl ether, by cells derepressed in a lipoprotein-free medium were similar in both experimental groups. Thus, the rise of LDL cholesterol with age would seem to be likely secondary to the higher rate of very-low-density lipoprotein production, as shown by other investigators.
ISSN:0304-324X
1423-0003
DOI:10.1159/000213855