Linkage and association scan for tanning ability in an isolated Mongolian population

Tanning ability is important, because it represents the ability of the skin to protect itself against ultraviolet (UV) radiation. Here, we sought to determine genetic regions associated with tanning ability. Skin pigmentation was measured at the outer forearm and buttock areas to represent facultati...

Full description

Saved in:
Bibliographic Details
Published in:BMB reports 2011-11, Vol.44 (11), p.741-746
Main Authors: Paik, Seung-Hwan, Kim, Hyun-Jin, Lee, Seung-Bok, Im, Sun-Wha, Ju, Young-Seok, Yeon, Je-Ho, Jo, Seong-Jin, Eun, Hee-Chul, Seo, Jeong-Sun, Kim, Jong-Il, Kwon, Oh-Sang
Format: Article
Language:Korean
Subjects:
Genetic association study
Linkage analysis
Microsatellite repeats
Single nucleotide polymorphism
Tanning
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tanning ability is important, because it represents the ability of the skin to protect itself against ultraviolet (UV) radiation. Here, we sought to determine genetic regions associated with tanning ability. Skin pigmentation was measured at the outer forearm and buttock areas to represent facultative and constitutive skin color, respectively. In our study population consisting of isolated Mongolian subjects, with common histories of environmental UV exposure during their nomadic life, facultative skin color adjusted by constitutive skin color was used to indicate tanning ability. Through linkage analysis and family-based association tests of 345 Mongolian subjects, we identified 2 potential linkage regions regulating tanning ability on 5q35.3 and 12q13.2, having 6 and 7 significant single nucleotide polymorphisms (SNPs), respectively. Those significant SNPs were located in or adjacent to potential candidate genes related to tanning ability: GRM6, ATF1, WNT1, and SILV/Pmel17. [BMB reports 2011; 44(11): 741-746]
ISSN:1976-6696
1976-670X