In vivo micronucleus test of 4-butylaniline and N-butylaniline to classify a chemical’s mutagenicity according to the globally harmonized system of classification and labelling of chemicals (GHS)

In vivo micronucleus tests were performed to investigate the mutagenic potential of 4-butylaniline and N-butylaniline, which are used in dye intermediates and organic intermediates respectively. Groups of 5 male ICR mice were treated with vehicle or 4-butylaniline for 2 consecutive days by oral gava...

Full description

Saved in:
Bibliographic Details
Published in:Journal of applied biological chemistry 2019-12, Vol.62 (4), p.355-359
Main Authors: Kim, Soo-Jin, Shin, Seo-ho, Kim, Hyun-ock, Rim, Kyung-Taek
Format: Article
Language:Korean
Subjects:
4-butylaniline
Genotoxicity
Micronucleus assay
N-butylaniline
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 359
container_issue 4
container_start_page 355
container_title Journal of applied biological chemistry
container_volume 62
creator Kim, Soo-Jin
Shin, Seo-ho
Kim, Hyun-ock
Rim, Kyung-Taek
description In vivo micronucleus tests were performed to investigate the mutagenic potential of 4-butylaniline and N-butylaniline, which are used in dye intermediates and organic intermediates respectively. Groups of 5 male ICR mice were treated with vehicle or 4-butylaniline for 2 consecutive days by oral gavage at concentrations of 0 (control), 64, 160, 400, and 1000 mg/kg. Statistically significant and dose-dependent increases were found for micronuclei frequencies in male mice (p
format article
fullrecord <record><control><sourceid>kiss_kisti</sourceid><recordid>TN_cdi_kisti_ndsl_JAKO201912063603421</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><kiss_id>3734673</kiss_id><sourcerecordid>3734673</sourcerecordid><originalsourceid>FETCH-LOGICAL-k501-1e4e83a8743b05c9f9c2abb6c5dc6dfaaf60d7ab34a1ef8befac99a6f67928513</originalsourceid><addsrcrecordid>eNpVjU1OwzAQRiMEEqVwAjbeIMEikv_iJMuqgrZQwYLuo4ljt6aOg2K3UlhxDQ7ERTgJCVRIrEYz3zfvHUUjShmP05yT42hE8lTEmHN6Gp15_4KxIDTDo-hz4dDe7BtUG9k2biet2nkUlA-o0YjH5S50FpyxxikErkKP_0-hQdKC90Z3CJDcqJ4D9uv9w6N6F2CtnJEm9JmUTVsZtx4-wkahtW1KsLZDG2jrxpk3VSHf-aDqQXxg9qxgGvcjtlAqawfCkB9EHl3P5s8359GJ7hd1cZjjaHV3u5rO4-XTbDGdLONtgklMFFcZgyzlrMSJzHUuKZSlkEklRaUBtMBVCiXjQJTOSqVB5jkILdKcZglh4-jqF7s1PpjCVd4W95OHJ4pJTigWTGDG6dC7_Ov54rU1NbRdwVLGRcrYN_tYgV4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>In vivo micronucleus test of 4-butylaniline and N-butylaniline to classify a chemical’s mutagenicity according to the globally harmonized system of classification and labelling of chemicals (GHS)</title><source>Free E-Journal (出版社公開部分のみ）</source><creator>Kim, Soo-Jin ; Shin, Seo-ho ; Kim, Hyun-ock ; Rim, Kyung-Taek</creator><creatorcontrib>Kim, Soo-Jin ; Shin, Seo-ho ; Kim, Hyun-ock ; Rim, Kyung-Taek</creatorcontrib><description>In vivo micronucleus tests were performed to investigate the mutagenic potential of 4-butylaniline and N-butylaniline, which are used in dye intermediates and organic intermediates respectively. Groups of 5 male ICR mice were treated with vehicle or 4-butylaniline for 2 consecutive days by oral gavage at concentrations of 0 (control), 64, 160, 400, and 1000 mg/kg. Statistically significant and dose-dependent increases were found for micronuclei frequencies in male mice (p &lt;0.05). These results suggest that 4-butylaniline can induce genetic effects in the micronuclei of male mouse bone marrow cells. Based on the positive results obtained in cytogenetic analyses of somatic cells in vivo, Globally Harmonized System of Classification and Labelling of Chemicals Category 2 was assigned. N-butylaniline was administered for 2 consecutive days by oral gavage to male ICR mice at dose of 0 (control), 64, 160, 400, and 800 mg/kg. Nbutylaniline tested negative for micronuclei induction in mice, although N-butylaniline was associated with micronucleus induction at the highest dose. Based on the negative results obtained for cytogenetic analyses of somatic cells in vivo, “Not Classified” was assigned.</description><identifier>ISSN: 1976-0442</identifier><identifier>EISSN: 2234-7941</identifier><language>kor</language><publisher>한국응용생명화학회</publisher><subject>4-butylaniline ; Genotoxicity ; Micronucleus assay ; N-butylaniline</subject><ispartof>Journal of applied biological chemistry, 2019-12, Vol.62 (4), p.355-359</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885</link.rule.ids></links><search><creatorcontrib>Kim, Soo-Jin</creatorcontrib><creatorcontrib>Shin, Seo-ho</creatorcontrib><creatorcontrib>Kim, Hyun-ock</creatorcontrib><creatorcontrib>Rim, Kyung-Taek</creatorcontrib><title>In vivo micronucleus test of 4-butylaniline and N-butylaniline to classify a chemical’s mutagenicity according to the globally harmonized system of classification and labelling of chemicals (GHS)</title><title>Journal of applied biological chemistry</title><addtitle>Journal of Applied Biological Chemistry</addtitle><description>In vivo micronucleus tests were performed to investigate the mutagenic potential of 4-butylaniline and N-butylaniline, which are used in dye intermediates and organic intermediates respectively. Groups of 5 male ICR mice were treated with vehicle or 4-butylaniline for 2 consecutive days by oral gavage at concentrations of 0 (control), 64, 160, 400, and 1000 mg/kg. Statistically significant and dose-dependent increases were found for micronuclei frequencies in male mice (p &lt;0.05). These results suggest that 4-butylaniline can induce genetic effects in the micronuclei of male mouse bone marrow cells. Based on the positive results obtained in cytogenetic analyses of somatic cells in vivo, Globally Harmonized System of Classification and Labelling of Chemicals Category 2 was assigned. N-butylaniline was administered for 2 consecutive days by oral gavage to male ICR mice at dose of 0 (control), 64, 160, 400, and 800 mg/kg. Nbutylaniline tested negative for micronuclei induction in mice, although N-butylaniline was associated with micronucleus induction at the highest dose. Based on the negative results obtained for cytogenetic analyses of somatic cells in vivo, “Not Classified” was assigned.</description><subject>4-butylaniline</subject><subject>Genotoxicity</subject><subject>Micronucleus assay</subject><subject>N-butylaniline</subject><issn>1976-0442</issn><issn>2234-7941</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpVjU1OwzAQRiMEEqVwAjbeIMEikv_iJMuqgrZQwYLuo4ljt6aOg2K3UlhxDQ7ERTgJCVRIrEYz3zfvHUUjShmP05yT42hE8lTEmHN6Gp15_4KxIDTDo-hz4dDe7BtUG9k2biet2nkUlA-o0YjH5S50FpyxxikErkKP_0-hQdKC90Z3CJDcqJ4D9uv9w6N6F2CtnJEm9JmUTVsZtx4-wkahtW1KsLZDG2jrxpk3VSHf-aDqQXxg9qxgGvcjtlAqawfCkB9EHl3P5s8359GJ7hd1cZjjaHV3u5rO4-XTbDGdLONtgklMFFcZgyzlrMSJzHUuKZSlkEklRaUBtMBVCiXjQJTOSqVB5jkILdKcZglh4-jqF7s1PpjCVd4W95OHJ4pJTigWTGDG6dC7_Ov54rU1NbRdwVLGRcrYN_tYgV4</recordid><startdate>20191231</startdate><enddate>20191231</enddate><creator>Kim, Soo-Jin</creator><creator>Shin, Seo-ho</creator><creator>Kim, Hyun-ock</creator><creator>Rim, Kyung-Taek</creator><general>한국응용생명화학회</general><scope>HZB</scope><scope>Q5X</scope><scope>JDI</scope></search><sort><creationdate>20191231</creationdate><title>In vivo micronucleus test of 4-butylaniline and N-butylaniline to classify a chemical’s mutagenicity according to the globally harmonized system of classification and labelling of chemicals (GHS)</title><author>Kim, Soo-Jin ; Shin, Seo-ho ; Kim, Hyun-ock ; Rim, Kyung-Taek</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-k501-1e4e83a8743b05c9f9c2abb6c5dc6dfaaf60d7ab34a1ef8befac99a6f67928513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>2019</creationdate><topic>4-butylaniline</topic><topic>Genotoxicity</topic><topic>Micronucleus assay</topic><topic>N-butylaniline</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Soo-Jin</creatorcontrib><creatorcontrib>Shin, Seo-ho</creatorcontrib><creatorcontrib>Kim, Hyun-ock</creatorcontrib><creatorcontrib>Rim, Kyung-Taek</creatorcontrib><collection>Korea Information Science Society (KISS)</collection><collection>Korean Studies Information Service System (KISS) B-Type</collection><collection>KoreaScience</collection><jtitle>Journal of applied biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Soo-Jin</au><au>Shin, Seo-ho</au><au>Kim, Hyun-ock</au><au>Rim, Kyung-Taek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo micronucleus test of 4-butylaniline and N-butylaniline to classify a chemical’s mutagenicity according to the globally harmonized system of classification and labelling of chemicals (GHS)</atitle><jtitle>Journal of applied biological chemistry</jtitle><addtitle>Journal of Applied Biological Chemistry</addtitle><date>2019-12-31</date><risdate>2019</risdate><volume>62</volume><issue>4</issue><spage>355</spage><epage>359</epage><pages>355-359</pages><issn>1976-0442</issn><eissn>2234-7941</eissn><abstract>In vivo micronucleus tests were performed to investigate the mutagenic potential of 4-butylaniline and N-butylaniline, which are used in dye intermediates and organic intermediates respectively. Groups of 5 male ICR mice were treated with vehicle or 4-butylaniline for 2 consecutive days by oral gavage at concentrations of 0 (control), 64, 160, 400, and 1000 mg/kg. Statistically significant and dose-dependent increases were found for micronuclei frequencies in male mice (p &lt;0.05). These results suggest that 4-butylaniline can induce genetic effects in the micronuclei of male mouse bone marrow cells. Based on the positive results obtained in cytogenetic analyses of somatic cells in vivo, Globally Harmonized System of Classification and Labelling of Chemicals Category 2 was assigned. N-butylaniline was administered for 2 consecutive days by oral gavage to male ICR mice at dose of 0 (control), 64, 160, 400, and 800 mg/kg. Nbutylaniline tested negative for micronuclei induction in mice, although N-butylaniline was associated with micronucleus induction at the highest dose. Based on the negative results obtained for cytogenetic analyses of somatic cells in vivo, “Not Classified” was assigned.</abstract><pub>한국응용생명화학회</pub><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1976-0442
ispartof Journal of applied biological chemistry, 2019-12, Vol.62 (4), p.355-359
issn 1976-0442
2234-7941
language kor
recordid cdi_kisti_ndsl_JAKO201912063603421
source Free E-Journal (出版社公開部分のみ）
subjects 4-butylaniline
Genotoxicity
Micronucleus assay
N-butylaniline
title In vivo micronucleus test of 4-butylaniline and N-butylaniline to classify a chemical’s mutagenicity according to the globally harmonized system of classification and labelling of chemicals (GHS)
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T01%3A50%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-kiss_kisti&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20vivo%20micronucleus%20test%20of%204-butylaniline%20and%20N-butylaniline%20to%20classify%20a%20chemical%E2%80%99s%20mutagenicity%20according%20to%20the%20globally%20harmonized%20system%20of%20classification%20and%20labelling%20of%20chemicals%20(GHS)&rft.jtitle=Journal%20of%20applied%20biological%20chemistry&rft.au=Kim,%20Soo-Jin&rft.date=2019-12-31&rft.volume=62&rft.issue=4&rft.spage=355&rft.epage=359&rft.pages=355-359&rft.issn=1976-0442&rft.eissn=2234-7941&rft_id=info:doi/&rft_dat=%3Ckiss_kisti%3E3734673%3C/kiss_kisti%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-k501-1e4e83a8743b05c9f9c2abb6c5dc6dfaaf60d7ab34a1ef8befac99a6f67928513%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rft_kiss_id=3734673&rfr_iscdi=true