Coordinating postmitotic nuclear pore complex assembly with abscission timing

Cells divide and accurately inherit genomic and cellular content through synchronized changes in cellular organization and chromosome dynamics. Although DNA segregation, nuclear reformation, and cytokinesis/abscission temporally overlap, little is known about how these distinct events are coordinate...

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Bibliographic Details
Published in:Nucleus (Austin, Tex.) Tex.), 2011-07, Vol.2 (4), p.283-288
Main Authors: Mackay, Douglas R., Ullman, Katharine S.
Format: Article
Language:English
Subjects:
Animals
Aurora Kinase B
Aurora Kinases
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cell Cycle Checkpoints
Cell Division
Cycle
Cytokinesis
Extra View
HeLa Cells
Humans
Landes
Mitosis
Nuclear Envelope - metabolism
Nuclear Pore - chemistry
Nuclear Pore - metabolism
Nuclear Pore Complex Proteins - metabolism
Nuclear Proteins - metabolism
Organogenesis
Protein-Serine-Threonine Kinases - metabolism
Proteins
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Summary:Cells divide and accurately inherit genomic and cellular content through synchronized changes in cellular organization and chromosome dynamics. Although DNA segregation, nuclear reformation, and cytokinesis/abscission temporally overlap, little is known about how these distinct events are coordinated to ensure accurate cell division. Recently, we found that disruption of postmitotic nuclear pore complex assembly, an essential aspect of the newly forming nuclear envelope, triggers an Aurora B-dependent delay in abscission. This delay is further characterized by mislocalized, aberrantly active Aurora B in the cytoplasm of midbody-stage cells. These results support a model in which an Aurora B-mediated abscission checkpoint provides surveillance of nuclear pore complex formation to ensure that elements of nuclear architecture are fully formed before daughter cells are physically separated. Here we discuss the process of nuclear pore complex assembly, describe potential mechanisms that may explain how this process could be coordinated with abscission, and postulate why such a checkpoint mechanism may exist.
ISSN:1949-1034
1949-1042
DOI:10.4161/nucl.2.4.16189