The calcium endocrine system of adolescent rhesus monkeys and controls before and after spaceflight

1  National Aeronautics and Space Administration Ames Research Center, Moffett Field 94035-1000; 2  University of California and the Veterans Affairs Medical Center, San Diego, California 92161; 3  Morehouse School of Medicine, Atlanta, Georgia 30310; and 4  Institute for Biomedical Problems, 123007...

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Published in:American journal of physiology: endocrinology and metabolism 2002-03, Vol.282 (3), p.E514-E521
Main Authors: Arnaud, Sara B, Navidi, Meena, Deftos, Leonard, Thierry-Palmer, Myrtle, Dotsenko, Rita, Bigbee, Allison, Grindeland, Richard E
Format: Article
Language:English
Subjects:
Aging
Alkaline Phosphatase - blood
Animals
Calcitonin - blood
Calcitriol - blood
Calcium - metabolism
Calcium - physiology
Creatinine - blood
Diet
Eating
Endocrine Glands - physiology
Homeostasis
Hydrocortisone - blood
Intestinal Absorption
Life Sciences (General)
Macaca mulatta
Parathyroid Hormone - blood
Phosphorus - blood
Space Flight
Space life sciences
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Summary:1  National Aeronautics and Space Administration Ames Research Center, Moffett Field 94035-1000; 2  University of California and the Veterans Affairs Medical Center, San Diego, California 92161; 3  Morehouse School of Medicine, Atlanta, Georgia 30310; and 4  Institute for Biomedical Problems, 123007 Moscow D-7, Russia The calcium endocrine system of nonhuman primates can be influenced by chairing for safety and the weightless environment of spaceflight. The serum of two rhesus monkeys flown on the Bion 11 mission was assayed pre- and postflight for vitamin D metabolites, parathyroid hormone, calcitonin, parameters of calcium homeostasis, cortisol, and indexes of renal function. Results were compared with the same measures from five monkeys before and after chairing for a flight simulation study. Concentrations of 1,25-dihydroxyvitamin D were 72% lower after the flight than before, and more than after chairing on the ground (57%, P  
ISSN:0193-1849
1522-1555
DOI:10.1152/ajpendo.00299.2001