Subcutaneous Four-Week Repeated Dose Toxicity Studies of Rice Cell-Derived Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor in Rats

Recombinant human granulocyte-macrophage colony stimulating factor (hGM-CSF) is a glycoprotein and hematopoietic growth factors that regulates the proliferation of myeloid precursor cells and activates mature granulocytes and macrophages. In a previous study, we reported that hGM-CSF could be produc...

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Published in:Toxicological research (Seoul) 2008, 24(4), , pp.315-320
Main Authors: Ji, J.E. (Chung-Ang University, Seoul, Republic of Korea), Lee, J.M. (Chung-Ang University, Seoul, Republic of Korea), Choi, J.M. (Chung-Ang University, Seoul, Republic of Korea), Choi, Y.H. (Chung-Ang University, Seoul, Republic of Korea), Kim, E.K. (Chung-Ang University, Seoul, Republic of Korea), Chu, S.J. (Chung-Ang University, Seoul, Republic of Korea), Kim, S.K. (Chung-Ang University, Seoul, Republic of Korea), Ahn, K.H. (Chung-Ang University, Seoul, Republic of Korea), Lee, D.H. (Chung-Ang University, Seoul, Republic of Korea), Kim, H.H. (Chung-Ang University, Seoul, Republic of Korea), Han, K.B. (Hanson Biotech Co., Ltd., Daejeon, Republic of Korea), Kim, D.K. (Chung-Ang University, Seoul, Republic of Korea), E-mail: proteinlab@hanmail.net
Format: Article
Language:English
Subjects:
Biomedicine
Pharmacology/Toxicology
RAT
RATA
RATS
Recombinant hGM-CSF
Repeated dose toxicity
Rice cells
SD rats
예방의학
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Summary:Recombinant human granulocyte-macrophage colony stimulating factor (hGM-CSF) is a glycoprotein and hematopoietic growth factors that regulates the proliferation of myeloid precursor cells and activates mature granulocytes and macrophages. In a previous study, we reported that hGM-CSF could be produced in transgenic rice cell suspension culture, termed rhGM-CSF. In the present study, we examined the repeated dose toxicity of rhGM-CSF in SD rats. The repeated dose toxicity study was performed at each dose of 50 and 200 ㎍/kg subcutaneous administration of rhGM-CSF everyday for 28-days period. The results did not show any changes in food and water intake. There were also no significant changes in both body and organ weights between the control and the tested groups. The hematological and blood biochemical parameters were statistically not different in all groups. These results suggest that rhGM-CSF may show no repeated dose toxicity in SD rats under the conditions.
ISSN:1976-8257
2234-2753
DOI:10.5487/TR.2008.24.4.315