Oscillometry-defined Small Airway Dysfunction in Patients with Chronic Obstructive Pulmonary Disease

The prevalence of small airway dysfunction (SAD) in patients with chronic obstructive pulmonary disease (COPD) across different ethnicities is poorly understood. This study aimed to estimate the prevalence of SAD in stable COPD patients. We conducted a cross-sectional study of 196 consecutive stable...

Full description

Saved in:
Bibliographic Details
Published in:Tuberculosis and respiratory diseases 2024, 87(2), 398, pp.165-175
Main Authors: Rath, Amit K, Sahu, Dibakar, De, Sajal
Format: Article
Language:English
Subjects:
chronic obstructive pulmonary disease
copd assessment test score
expiratory flow limitation at tidal breaths
Original
oscillometry
small airway dysfunction
내과학
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c445t-2e1608ec46d258d2cdbb6eff595fc4562b92779d05016531b8f438154aa805703
container_end_page 175
container_issue 2
container_start_page 165
container_title Tuberculosis and respiratory diseases
container_volume 87
creator Rath, Amit K
Sahu, Dibakar
De, Sajal
description The prevalence of small airway dysfunction (SAD) in patients with chronic obstructive pulmonary disease (COPD) across different ethnicities is poorly understood. This study aimed to estimate the prevalence of SAD in stable COPD patients. We conducted a cross-sectional study of 196 consecutive stable COPD patients. We measured pre- and post-bronchodilator lung function and respiratory impedance. The severity of COPD and lung function abnormalities were graded according to the GOLD guidelines. SAD was defined as either R5-19 > upper limit of normal and/or X5 < lower limit of normal. The cohort consisted of 95.9% men, with a mean age of 66.3 years. The mean FEV1% predicted and the median CAT scores of the cohort were 56.4% and 14, respectively. The prevalence of post-bronchodilator SAD across GOLD grades one to 4 was 14.3%, 51.1%, 91%, and 100%, respectively. The post-bronchodilator SAD and expiratory flow limitation at tidal breath (EFLT) were 62.8% (95% CI: 56.1-69.9) and 28.1% (95% CI: 21.9-34.2), respectively. COPD patients with SAD had higher CAT scores (15.5 vs. 12.8, p=
doi_str_mv 10.4046/trd.2023.0139
format article
fullrecord <record><control><sourceid>proquest_nrf_k</sourceid><recordid>TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_10419580</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_6521efd45326495f80894f1ee534cf97</doaj_id><sourcerecordid>2915569919</sourcerecordid><originalsourceid>FETCH-LOGICAL-c445t-2e1608ec46d258d2cdbb6eff595fc4562b92779d05016531b8f438154aa805703</originalsourceid><addsrcrecordid>eNpVkktvEzEURkcIRNPCki2aJUKa4HfsFYpSKJEqpYKytjx-NG4942J7WuXf4ySloqsr2ecef7K-pvkAwZwAwr6UZOYIIDwHEItXzQwBQDsGOXndzOAC8w5TzE6a05xvAWBYcP62OcEcIco4mzVmk7UPIQ62pF1nrPOjNe2vQYXQLn16VLv2fJfdNOri49j6sb1Sxdux5PbRl2272qY4et1u-lzSVKEH215NYYijSnXVZ6uyfde8cSpk-_5pnjW_v3-7Xv3oLjcX69XystOE0NIhCxngVhNmEOUGadP3zDpHBXWaUIZ6gRYLYQAFkFEMe-4I5pASpTigC4DPms9H75icvNNeRuUP8ybKuySXP6_XEgICBeV7eH2ETVS38j75oSY-bBwOYrqRKhWvg5WMImidIRQjRmoYDrggDlpLMdFOLKrr69F1P_WDNbr-T1LhhfTlzei3NdRDTSMEYBBWw6cnQ4p_JpuLHHzWNgQ12jhliQSklAkBRUW7I6pTzDlZ9_wOBHLfCVk7IfedkPtOVP7j_-Ge6X8lwH8BVv6ynA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2915569919</pqid></control><display><type>article</type><title>Oscillometry-defined Small Airway Dysfunction in Patients with Chronic Obstructive Pulmonary Disease</title><source>PubMed Central</source><creator>Rath, Amit K ; Sahu, Dibakar ; De, Sajal</creator><creatorcontrib>Rath, Amit K ; Sahu, Dibakar ; De, Sajal</creatorcontrib><description>The prevalence of small airway dysfunction (SAD) in patients with chronic obstructive pulmonary disease (COPD) across different ethnicities is poorly understood. This study aimed to estimate the prevalence of SAD in stable COPD patients. We conducted a cross-sectional study of 196 consecutive stable COPD patients. We measured pre- and post-bronchodilator lung function and respiratory impedance. The severity of COPD and lung function abnormalities were graded according to the GOLD guidelines. SAD was defined as either R5-19 &gt; upper limit of normal and/or X5 &lt; lower limit of normal. The cohort consisted of 95.9% men, with a mean age of 66.3 years. The mean FEV1% predicted and the median CAT scores of the cohort were 56.4% and 14, respectively. The prevalence of post-bronchodilator SAD across GOLD grades one to 4 was 14.3%, 51.1%, 91%, and 100%, respectively. The post-bronchodilator SAD and expiratory flow limitation at tidal breath (EFLT) were 62.8% (95% CI: 56.1-69.9) and 28.1% (95% CI: 21.9-34.2), respectively. COPD patients with SAD had higher CAT scores (15.5 vs. 12.8, p=&lt;0.01); poor lung function (FEV1% predicted 46.6% vs. 77.8%, p&lt;0.01); lower diffusion capacity for CO (4.8 vs. 5.63 mmol/min/kPa, p&lt;0.01); hyperinflation (RV/TLC % predicted 159.7% vs. 129%, p&lt;0.01), and shorter 6-min walk distance (367.5 vs. 390 m, p=0.03). SAD is present across all severities of COPD, and the prevalence increases with disease severity. SAD is associated with poor lung function and higher symptom burden. The presence of EFLT indicates severe SAD.</description><identifier>ISSN: 1738-3536</identifier><identifier>EISSN: 2005-6184</identifier><identifier>DOI: 10.4046/trd.2023.0139</identifier><identifier>PMID: 38225686</identifier><language>eng</language><publisher>Korea (South): The Korean Academy of Tuberculosis and Respiratory Diseases</publisher><subject>chronic obstructive pulmonary disease ; copd assessment test score ; expiratory flow limitation at tidal breaths ; Original ; oscillometry ; small airway dysfunction ; 내과학</subject><ispartof>Tuberculosis and Respiratory Diseases, 2024, 87(2), 398, pp.165-175</ispartof><rights>Copyright © 2024 The Korean Academy of Tuberculosis and Respiratory Diseases 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c445t-2e1608ec46d258d2cdbb6eff595fc4562b92779d05016531b8f438154aa805703</cites><orcidid>0000-0002-8349-125X ; 0000-0003-0834-9234</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10990611/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10990611/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38225686$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART003067957$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Rath, Amit K</creatorcontrib><creatorcontrib>Sahu, Dibakar</creatorcontrib><creatorcontrib>De, Sajal</creatorcontrib><title>Oscillometry-defined Small Airway Dysfunction in Patients with Chronic Obstructive Pulmonary Disease</title><title>Tuberculosis and respiratory diseases</title><addtitle>Tuberc Respir Dis (Seoul)</addtitle><description>The prevalence of small airway dysfunction (SAD) in patients with chronic obstructive pulmonary disease (COPD) across different ethnicities is poorly understood. This study aimed to estimate the prevalence of SAD in stable COPD patients. We conducted a cross-sectional study of 196 consecutive stable COPD patients. We measured pre- and post-bronchodilator lung function and respiratory impedance. The severity of COPD and lung function abnormalities were graded according to the GOLD guidelines. SAD was defined as either R5-19 &gt; upper limit of normal and/or X5 &lt; lower limit of normal. The cohort consisted of 95.9% men, with a mean age of 66.3 years. The mean FEV1% predicted and the median CAT scores of the cohort were 56.4% and 14, respectively. The prevalence of post-bronchodilator SAD across GOLD grades one to 4 was 14.3%, 51.1%, 91%, and 100%, respectively. The post-bronchodilator SAD and expiratory flow limitation at tidal breath (EFLT) were 62.8% (95% CI: 56.1-69.9) and 28.1% (95% CI: 21.9-34.2), respectively. COPD patients with SAD had higher CAT scores (15.5 vs. 12.8, p=&lt;0.01); poor lung function (FEV1% predicted 46.6% vs. 77.8%, p&lt;0.01); lower diffusion capacity for CO (4.8 vs. 5.63 mmol/min/kPa, p&lt;0.01); hyperinflation (RV/TLC % predicted 159.7% vs. 129%, p&lt;0.01), and shorter 6-min walk distance (367.5 vs. 390 m, p=0.03). SAD is present across all severities of COPD, and the prevalence increases with disease severity. SAD is associated with poor lung function and higher symptom burden. The presence of EFLT indicates severe SAD.</description><subject>chronic obstructive pulmonary disease</subject><subject>copd assessment test score</subject><subject>expiratory flow limitation at tidal breaths</subject><subject>Original</subject><subject>oscillometry</subject><subject>small airway dysfunction</subject><subject>내과학</subject><issn>1738-3536</issn><issn>2005-6184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkktvEzEURkcIRNPCki2aJUKa4HfsFYpSKJEqpYKytjx-NG4942J7WuXf4ySloqsr2ecef7K-pvkAwZwAwr6UZOYIIDwHEItXzQwBQDsGOXndzOAC8w5TzE6a05xvAWBYcP62OcEcIco4mzVmk7UPIQ62pF1nrPOjNe2vQYXQLn16VLv2fJfdNOri49j6sb1Sxdux5PbRl2272qY4et1u-lzSVKEH215NYYijSnXVZ6uyfde8cSpk-_5pnjW_v3-7Xv3oLjcX69XystOE0NIhCxngVhNmEOUGadP3zDpHBXWaUIZ6gRYLYQAFkFEMe-4I5pASpTigC4DPms9H75icvNNeRuUP8ybKuySXP6_XEgICBeV7eH2ETVS38j75oSY-bBwOYrqRKhWvg5WMImidIRQjRmoYDrggDlpLMdFOLKrr69F1P_WDNbr-T1LhhfTlzei3NdRDTSMEYBBWw6cnQ4p_JpuLHHzWNgQ12jhliQSklAkBRUW7I6pTzDlZ9_wOBHLfCVk7IfedkPtOVP7j_-Ge6X8lwH8BVv6ynA</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Rath, Amit K</creator><creator>Sahu, Dibakar</creator><creator>De, Sajal</creator><general>The Korean Academy of Tuberculosis and Respiratory Diseases</general><general>대한결핵및호흡기학회</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><scope>ACYCR</scope><orcidid>https://orcid.org/0000-0002-8349-125X</orcidid><orcidid>https://orcid.org/0000-0003-0834-9234</orcidid></search><sort><creationdate>20240401</creationdate><title>Oscillometry-defined Small Airway Dysfunction in Patients with Chronic Obstructive Pulmonary Disease</title><author>Rath, Amit K ; Sahu, Dibakar ; De, Sajal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-2e1608ec46d258d2cdbb6eff595fc4562b92779d05016531b8f438154aa805703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>chronic obstructive pulmonary disease</topic><topic>copd assessment test score</topic><topic>expiratory flow limitation at tidal breaths</topic><topic>Original</topic><topic>oscillometry</topic><topic>small airway dysfunction</topic><topic>내과학</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rath, Amit K</creatorcontrib><creatorcontrib>Sahu, Dibakar</creatorcontrib><creatorcontrib>De, Sajal</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><collection>Korean Citation Index</collection><jtitle>Tuberculosis and respiratory diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rath, Amit K</au><au>Sahu, Dibakar</au><au>De, Sajal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oscillometry-defined Small Airway Dysfunction in Patients with Chronic Obstructive Pulmonary Disease</atitle><jtitle>Tuberculosis and respiratory diseases</jtitle><addtitle>Tuberc Respir Dis (Seoul)</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>87</volume><issue>2</issue><spage>165</spage><epage>175</epage><pages>165-175</pages><issn>1738-3536</issn><eissn>2005-6184</eissn><abstract>The prevalence of small airway dysfunction (SAD) in patients with chronic obstructive pulmonary disease (COPD) across different ethnicities is poorly understood. This study aimed to estimate the prevalence of SAD in stable COPD patients. We conducted a cross-sectional study of 196 consecutive stable COPD patients. We measured pre- and post-bronchodilator lung function and respiratory impedance. The severity of COPD and lung function abnormalities were graded according to the GOLD guidelines. SAD was defined as either R5-19 &gt; upper limit of normal and/or X5 &lt; lower limit of normal. The cohort consisted of 95.9% men, with a mean age of 66.3 years. The mean FEV1% predicted and the median CAT scores of the cohort were 56.4% and 14, respectively. The prevalence of post-bronchodilator SAD across GOLD grades one to 4 was 14.3%, 51.1%, 91%, and 100%, respectively. The post-bronchodilator SAD and expiratory flow limitation at tidal breath (EFLT) were 62.8% (95% CI: 56.1-69.9) and 28.1% (95% CI: 21.9-34.2), respectively. COPD patients with SAD had higher CAT scores (15.5 vs. 12.8, p=&lt;0.01); poor lung function (FEV1% predicted 46.6% vs. 77.8%, p&lt;0.01); lower diffusion capacity for CO (4.8 vs. 5.63 mmol/min/kPa, p&lt;0.01); hyperinflation (RV/TLC % predicted 159.7% vs. 129%, p&lt;0.01), and shorter 6-min walk distance (367.5 vs. 390 m, p=0.03). SAD is present across all severities of COPD, and the prevalence increases with disease severity. SAD is associated with poor lung function and higher symptom burden. The presence of EFLT indicates severe SAD.</abstract><cop>Korea (South)</cop><pub>The Korean Academy of Tuberculosis and Respiratory Diseases</pub><pmid>38225686</pmid><doi>10.4046/trd.2023.0139</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-8349-125X</orcidid><orcidid>https://orcid.org/0000-0003-0834-9234</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1738-3536
ispartof Tuberculosis and Respiratory Diseases, 2024, 87(2), 398, pp.165-175
issn 1738-3536
2005-6184
language eng
recordid cdi_nrf_kci_oai_kci_go_kr_ARTI_10419580
source PubMed Central
subjects chronic obstructive pulmonary disease
copd assessment test score
expiratory flow limitation at tidal breaths
Original
oscillometry
small airway dysfunction
내과학
title Oscillometry-defined Small Airway Dysfunction in Patients with Chronic Obstructive Pulmonary Disease
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T16%3A43%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_nrf_k&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Oscillometry-defined%20Small%20Airway%20Dysfunction%20in%20Patients%20with%20Chronic%20Obstructive%20Pulmonary%20Disease&rft.jtitle=Tuberculosis%20and%20respiratory%20diseases&rft.au=Rath,%20Amit%20K&rft.date=2024-04-01&rft.volume=87&rft.issue=2&rft.spage=165&rft.epage=175&rft.pages=165-175&rft.issn=1738-3536&rft.eissn=2005-6184&rft_id=info:doi/10.4046/trd.2023.0139&rft_dat=%3Cproquest_nrf_k%3E2915569919%3C/proquest_nrf_k%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c445t-2e1608ec46d258d2cdbb6eff595fc4562b92779d05016531b8f438154aa805703%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2915569919&rft_id=info:pmid/38225686&rfr_iscdi=true