KASL Clinical Practice Guidelines for Noninvasive Tests to Assess Liver Fibrosis in Chronic Liver Disease

Level of evidence and grade of recommendations The literature collected for evidence was analyzed through systematic review, and the level of evidence was classified based on the revised Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) with modifications (Table 1). The dec...

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Published in:Clinical and molecular hepatology 2024, 30(0), , pp.5-105
Main Authors: Kim, Mi Na, Han, Ji Won, An, Jihyun, Kim, Beom Kyung, Jin, Young-Joo, Kim, Seung-Seob, Lee, Minjong, Lee, Han Ah, Cho, Yuri, Kim, Hee Yeon, Shin, Yu Rim, Yu, Jung Hwan, Kim, Moon Young, Choi, YoungRok, Chon, Young Eun, Cho, Eun Ju, Lee, Eun Joo, Kim, Sang Gyune, Kim, Won, Jun, Dae Won, Kim, Seung Up
Format: Article
Language:English
Subjects:
Biopsy
Cholangitis
chronic liver disease
Clinical medicine
Clinical practice guidelines
Committees
Cost analysis
guidelines
Hepatitis
Hepatology
Inflammation
Liver cancer
Liver cirrhosis
Liver diseases
liver fibrosis
Metabolism
noninvasive test
Patients
Pediatrics
Preferences
Special Issue
Surgeons
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Summary:Level of evidence and grade of recommendations The literature collected for evidence was analyzed through systematic review, and the level of evidence was classified based on the revised Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) with modifications (Table 1). The decision to initiate treatment for CLD and its prognosis are primarily determined by the degree of liver fibrosis and its progression, as well as the risk of developing cirrhosis. [...]far, liver biopsy has been the standard test for diagnosing intrahepatic inflammation, steatosis, and fibrosis. [...]there are drawbacks such as high cost, invasiveness, risk of complications, potential for interpretation errors based on subjective judgment, and sample error due to small tissue samples [1,2]. [...]in real-world clinical practice, NITs based on imaging studies are commonly used, such as abdominal ultrasound and/or panels using serum markers. [...]the AST-to-ALT ratio (AAR) increases, allowing for
ISSN:2287-2728
2287-285X
2287-285X
DOI:10.3350/cmh.2024.0506