Alterations in dopamine and glutamate neurotransmission in tetrahydrobiopterin deficient spr-/- mice: relevance to schizophrenia

Tetrahydrobiopterin (BH₄) is a pivotal cofactor for enzymes responsible for the synthesis and release of monoamine neurotransmitters including dopamine and serotonin as well as the release of glutamate. Deficiencies in BH₄ levels and reduced activities of BH₄-associated enzymes have been recently re...

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Bibliographic Details
Published in:BMB reports 2010, 43(9), , pp.593-598
Main Authors: Choi, Y.K., Harvard Medical School, Boston, MA, USA, Tarazi, Frank I., Harvard Medical School, Boston, MA, USA
Format: Article
Language:English
Subjects:
ACIDE GLUTAMIQUE
ACIDO GLUTAMICO
DOPAMINA
DOPAMINE
GLUTAMIC ACID
Schizophrenia
Sepiapterin reductase gene
SEROTONIN
SEROTONINA
SEROTONINE
Tetrahydrobiopterin
화학
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Summary:Tetrahydrobiopterin (BH₄) is a pivotal cofactor for enzymes responsible for the synthesis and release of monoamine neurotransmitters including dopamine and serotonin as well as the release of glutamate. Deficiencies in BH₄ levels and reduced activities of BH₄-associated enzymes have been recently reported in patients with schizophrenia. Accordingly, it is possible that abnormalities in the biochemical cascades regulated by BH₄ may alter DA, 5-HT and Glu neurotransmission, and consequently contribute to the pathophysiology of different neuropsychiatric diseases including schizophrenia. The development of a novel strain of mutant mice that is deficient in BH₄ by knocking out the expression of a functional sepiapterin reductase gene (spr-/-) has added new insights into the potential role of BH₄ in the pathophysiology and improved treatment of schizophrenia.
ISSN:1976-6696
1976-670X
DOI:10.5483/BMBRep.2010.43.9.593