Infectious Complications after Prostate Biopsy: A Prospective Multicenter Prostate Biopsy Study

• Published in: Urogenital tract infection 2016, 11(1), , pp.17-24
• Main Authors: Hwang, Eu Chang, Yu, Ho Song, Jung, Seung Il, Kwon, Dong Deuk, Lee, Sun Ju, Kim, Tae-Hyoung, Chang, In Ho, Yoon, Hana, Shim, Bongsuk, Kim, Kwang Hyun, Lee, Donghyun, Huh, Jung-Sik, Lim, Dong Hoon, Jo, Won Jin, Min, Seung Ki, Lee, Gilho, Kim, Ki Ho, Kim, Tae Hwan, Lee, Seo Yeon, Yang, Seung Ok, Chung, Jae Min, Lee, Sang Don, Han, Chang Hee, Bae, Sang Rak, Choe, Hyun Sop, Lee, Seung-Ju, Chung, Hong, Yang, Seung Woo, Park, Sung Woon, Kim, Young Ho, Kim, Tae Hyo, Cho, Won Yeol, Han, June Hyun, Cho, Yong-Hyun, Ha, U-Syn, Park, Heung Jae
• Format: Article
• Language: English
• Subjects: 비뇨기과학
• ISSN: 2465-8243; 2465-8510
• DOI: 10.14777/uti.2016.11.1.17

Purpose: Recent studies have highlighted an increasing trend of infectious complications due to fluoroquinolone-resistant organisms among men undergoing transrectal prostate biopsy. This study evaluated the current incidence of infective complications after trans-rectal prostate biopsy for identification of risk factors in Korean men who received fluoroquinolone prophylaxis.Materials and Methods: A prospective, multicenter study was conducted in Korea from January to December 2015. Prostate biopsies performed with fluoroqui-nolone prophylaxis during 3 months in each center were included. A pre-biopsy questionnaire was used for identification of patient characteristics. Clinical variables including underlying disease, antibiotic prophylaxis, enema, povidone- iodine cleansing of the rectum, and infectious complications were evaluated. The primary outcome was the post-biopsy infection rate after fluoroquinolone prophylaxis. Univariable and multivariable analyses were used for identification of risk factors for infectious complications.Results: The study included 827 patients, of whom 93 patients (11.2%) reported receiving antibiotics in the previous 6 months and 2.5% had a history of prostatitis. The infectious complication rate was 2.2%. Post-biopsy sepsis was reported in 2 patients (0.2%). In multivariable analysis predictors of post-biopsy sepsis included person performing biopsy (adjusted odds ratio [OR], 4.05; 95% confidence interval [CI], 1.31-12.5; p=0.015) and operation history within 6 months (adjusted OR, 5.65; 95% CI, 1.74-18.2; p=0.004).Conclusions: The post-prostate biopsy infectious complication rate in this study was 2.2%. Person performing biopsy (non-urologists) and recent operation history were independent risk factors for infectious complications after trans-rectal prostate biopsy. KCI Citation Count: 1