Effects of material properties and speed of compression on microbial survival and tensile strength in diclofenac tablet formulations

• Published in: Archives of pharmacal research 2013, 36(3), , pp.273-281
• Main Authors: Ayorinde, J. O., Itiola, O. A., Odeniyi, M. A.
• Format: Article
• Language: English
• Subjects: Bacillus subtilis - isolation & purification; Bacillus subtilis - physiology; Chemistry, Pharmaceutical - methods; Chemistry, Pharmaceutical - standards; Compressive Strength; Diclofenac - chemical synthesis; Diclofenac - standards; Drug Contamination - prevention & control; Medicine; Pharmacology/Toxicology; Pharmacy; Research Article; Tablets; Tensile Strength; Time Factors; 약학
• ISSN: 0253-6269; 1976-3786
• DOI: 10.1007/s12272-013-0027-4

A work has been done to study the effects of material properties and compression speed on microbial survival and tensile strength in diclofenac tablet formulations. Tablets were produced from three formulations containing diclofenac and different excipients (DC, DL and DDCP). Two types of machines (Hydraulic hand press and single punch press), which compress the tablets at different speeds, were used. The compression properties of the tablets were analyzed using Heckel and Kawakita equations. A 3-dimensional plot was produced to determine the relationship between the tensile strength, compression speed and percentage survival of Bacillus subtilis in the diclofenac tablets. The mode of consolidation of diclofenac was found to depends on the excipient used in the formulation. DC deformed mainly by plastic flow with the lowest P y and P k values. DL deformed plastically at the initial stage, followed by fragmentation at the later stage of compression, whereas DDCP deformed mainly by fragmentation with the highest P y and P k values. The ranking of the percentage survival of B. subtilis in the formulations was DDCP > DL > DC, whereas the ranking of the tensile strength of the tablets was DDCP > DL > DC. Tablets produced on a hydraulic hand press with a lower compression speed had a lower percentage survival of microbial contaminants than those produced on a single punch press, which compressed the tablets at a much higher speed. The mode of consolidation of the materials and the speed at which tablet compression is carried out have effects on both the tensile strength of the tablets and the extent of destruction of microbial contaminants in diclofenac tablet formulations.