Relationship between obesity and N-terminal brain natriuretic Peptide level as a prognostic value after acute myocardial infarction

• Published in: Korean circulation journal 2010, 40(11), , pp.558-564
• Main Authors: Choi, Seon Gyu, Jeong, Myung Ho, Ahn, Youngkeun, Cho, Jeong Gwan, Kang, Jung Chaee, Chae, Shung Chull, Hur, Seung Ho, Hong, Taek Jong, Kim, Young Jo, Seong, In Whan, Chae, Jei Keon, Rhew, Jay Young, Chae, In Ho, Cho, Myeong Chan, Bae, Jang Ho, Rha, Seung Woon, Kim, Chong Jin, Choi, Donghoon, Jang, Yang Soo, Yoon, Junghan, Chung, Wook Sung, Seung, Ki Bae, Park, Seung Jung
• Format: Article
• Language: English
• Subjects: Original; 내과학
• ISSN: 1738-5520; 1738-5555
• DOI: 10.4070/kcj.2010.40.11.558

Recently, the prognostic value of N-terminal brain natriuretic peptide (NT-proBNP) in acute coronary syndrome has been demonstrated in many studies. However, NT-proBNP levels are influenced by various factors such as sex, age, renal function, heart failure severity, and obesity. NT-proBNP concentrations tend to decrease with higher body mass index (BMI). The aim of this study was to examine the influence of obesity on NT-proBNP as a predictive prognostic factor in acute myocardial infarction (AMI) patients. Using data from the Korea Acute Myocardial Infarction Registry (January 2005 to September 2008), 2,736 AMI patients were included in this study. These patients were divided into men (n=1,972, 70%) and women (n=764, 30%), and were grouped according to their BMIs. Major adverse cardiac events (MACE) during 1 year clinical follow-up were evaluated. NT-proBNP was significantly higher in lower BMI (p