Effect of the licorice flavonoid isoliquiritigenin on the sleep architecture and profile in mice

The sleep-promoting effect of isoliquiritigenin (ILTG) was investigated by analyzing the sleep architecture in mice. A hypnotic diazepam (DZP, 2 mg/kg) significantly decreased sleep latency by 39.7% and increased the amount of non-rapid eye movement sleep (NREMS) by 103.8% for the first 3 h after ad...

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Published in:Food science and biotechnology 2012, 21(4), , pp.1221-1225
Main Authors: Cho, S.M., Korea Food Research Institute, Seongnam, Republic of Korea, Yoon, M.S., Korea Food Research Institute, Seongnam, Republic of Korea, Kim, D.S., Korea Food Research Institute, Seongnam, Republic of Korea, Kim, J.S., Gyeongsang National University, Tongyeong, Republic of Korea, Yang, H.J., Korea Food Research Institute, Seongnam, Republic of Korea, Lee, C.H., Korea Food Research Institute, Seongnam, Republic of Korea, Kim, I.H., Korea Food Research Institute, Seongnam, Republic of Korea, Shimizu, Makoto, The University of Tokyo, Tokyo, Japan, Han, D.S., Korea Food Research Institute, Seongnam, Republic of Korea
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Diazepam
electroencephalogram
electromyogram
Flavonoids
Food Science
Glycyrrhiza glabra
Hypnotics
isoliquiritigenin
LIQUORICE
Nutrition
REGALIZ
REGLISSE
Research Note
Sleep (NREM)
sleep architecture
sleep-promoting effect
식품과학
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Summary:The sleep-promoting effect of isoliquiritigenin (ILTG) was investigated by analyzing the sleep architecture in mice. A hypnotic diazepam (DZP, 2 mg/kg) significantly decreased sleep latency by 39.7% and increased the amount of non-rapid eye movement sleep (NREMS) by 103.8% for the first 3 h after administration. ILTG (50 mg/kg) also produced a significant decrease in sleep latency (30.7%) and an increase in the amount of NREMS (61.1%). DZP significantly decreased delta (0.5-4 Hz) activity as compared with the vehicle; however, ILTG did not alter the delta activity. These results mean that ILTG induces sleep similar to physiological sleep without a decline in sleep quality.
ISSN:1226-7708
2092-6456
DOI:10.1007/s10068-012-0160-8