Genetic Variations of Tyrosine Hydroxylase in the Pathogenesis of Hypertension

One of the major pathophysiological features of primary hypertension is an inappropriate activation of the sympathetic nervous system, which is mediated by excessive synthesis and secretion of catecholamine into the blood. Tyrosine hydroxylase (TH), a rate-limiting enzyme in the synthesis of catecho...

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Bibliographic Details
Published in:Electrolyte & blood pressure : E & BP 2016, 14(2), , pp.21-26
Main Authors: Lee, Yu Ho, Kim, Yang Gyun, Moon, Ju-Young, Kim, Jin Sug, Jeong, Kyung-Hwan, Lee, Tae Won, Ihm, Chun-Gyoo, Lee, Sang Ho
Format: Article
Language:English
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Review
의약학
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Summary:One of the major pathophysiological features of primary hypertension is an inappropriate activation of the sympathetic nervous system, which is mediated by excessive synthesis and secretion of catecholamine into the blood. Tyrosine hydroxylase (TH), a rate-limiting enzyme in the synthesis of catecholamine, has been highlighted because genetic variations of could alter the activity of the sympathetic nervous system activity and subsequently contribute to the pathogenesis of hypertension. Here, we discuss the role of TH as a regulator of sympathetic activity and review several studies that investigated the relationship between genetic variations of and hypertension.
ISSN:1738-5997
2092-9935
DOI:10.5049/EBP.2016.14.2.21