Higher Expression of Toll-like Receptors 3, 7, 8, and 9 in Pityriasis Rosea

Pityriasis rosea (PR) is a common papulosquamous skin disease in which an infective agent may be implicated. Toll-like receptors (TLRs) play an important role in immune responses and in the pathophysiology of inflammatory skin diseases. Our aim was to determine the possible roles of TLRs 3, 7, 8, an...

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Bibliographic Details
Published in:Journal of pathology and translational medicine 2017, 51(2), , pp.148-151
Main Authors: El-Ela, Mostafa Abou, El-Komy, Mohamed, Hay, Rania Abdel, Hegazy, Rehab, Sharobim, Amin, Rashed, Laila, Amr, Khalda
Format: Article
Language:English
Subjects:
Age
Biopsy
Dermatology
Gene expression
Immunity, innate
Infections
Influenza
Laboratories
Methods
Original
Pathogenesis
Pityriasis rosea
Polymerase chain reaction
Reverse transcriptase polymerase chain reaction
Skin diseases
Software
Studies
Toll-like receptors
Viral infections
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Summary:Pityriasis rosea (PR) is a common papulosquamous skin disease in which an infective agent may be implicated. Toll-like receptors (TLRs) play an important role in immune responses and in the pathophysiology of inflammatory skin diseases. Our aim was to determine the possible roles of TLRs 3, 7, 8, and 9 in the pathogenesis of PR. Twenty-four PR patients and 24 healthy individuals (as controls) were included in this case control study. All recruits were subjected to routine laboratory investigations. Biopsies were obtained from one active PR lesion and from healthy skin of controls for the detection of TLR 3, 7, 8, and 9 gene expression using real-time polymerase chain reaction. This study included 24 patients (8 females and 16 males) with active PR lesions, with a mean age of 28.62 years. Twenty four healthy age- and sex-matched individuals were included as controls (8 females and 16 males, with a mean age of 30.83 years). The results of the routine laboratory tests revealed no significant differences between both groups. Significantly elevated expression of all studied TLRs were detected in PR patients relative to healthy controls (p < .001). TLRs 3, 7, 8, and 9 might be involved in the pathogenesis of PR.
ISSN:2383-7837
2383-7845
DOI:10.4132/jptm.2016.09.09