The polymorphisms of bovine PCSK1 gene and their associations with growth traits

• Published in: Genes & genomics 2011, 33(1), , pp.57-63
• Main Authors: Shan, Limin, Xuzhou Normal University, Xuzhou, Jiangsu, China, Sun, Jiajie, Northwest AnF University, Yangling, Shaanxi, China, Zhang, Chunlei, Xuzhou Normal University, Xuzhou, Jiangsu, China, Fang, Xingtang, Xuzhou Normal University, Xuzhou, Jiangsu, China, Lei, Chuzhao, Northwest AnF University, Yangling, Shaanxi, China, Lan, Xianyong, Northwest AnF University, Yangling, Shaanxi, China, Chen, Hong, Xuzhou Normal University, Xuzhou, Jiangsu, China
• Format: Article
• Language: English
• Subjects: Animal Genetics and Genomics; Biomedical and Life Sciences; BOVIN; CATTLE; GANADO BOVINO; Growth traits; Human Genetics; Life Sciences; Microbial Genetics and Genomics; MUTACION; MUTATION; PCSK1 gene; Plant Genetics and Genomics; Research Article; SSCP; 생물학
• ISSN: 1976-9571; 2092-9293
• DOI: 10.1007/s13258-010-0049-y

Proprotein convertase 1 (PCSK1) is an endopeptidase involved in proteolytic processing of peptide hormone precursors in granules of the regulated secretory pathway of endocrine cells and mutations in PCSK1 gene are thought to cause obesity. In the present study, based on PCR-SSCP and DNA sequencing methods, polymorphisms of the PCSK1 gene were detected in 858 individuals from five breeds (Nanyang cattle, Qinchuan cattle, Jiaxian cattle, Luxi cattle and Chinese Holstein). The results showed that only P∧8 locus showed polymorphisms and 3 synonymous SNPs of PCSK1 gene were identified. Additionally, significant statistical difference was found in bovine birth weight and diplotype MM were 7.35% higher than diplotype XY.