Performance Evaluation of the Beckman Coulter DxN VERIS Hepatitis B Virus (HBV) Assay in Comparison With the Abbott RealTime HBV Assay

The detection and quantification of hepatitis B virus (HBV) DNA plays an important role in diagnosing and monitoring HBV infection as well as in assessing the therapeutic response. We compared the analytical performance of a random access, fully automated HBV assay-DxN VERIS Molecular Diagnostics Sy...

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Bibliographic Details
Published in:Annals of laboratory medicine 2019, 39(1), , pp.86-90
Main Authors: Park, Joonhong, Cho, Hanwool, Choi, Seung Jun, Lee, Gun Dong, Sin, Sang Hyun, Ryu, Ji Hyeong, Park, Hye Sun, Lee, Hyeyoung, Kim, Yonggoo, Oh, Eun Jee
Format: Article
Language:English
Subjects:
Brief Communication
DNA, Viral - blood
Drug Resistance, Viral - genetics
Genotype
Hepatitis B - diagnosis
Hepatitis B - virology
Hepatitis B virus - genetics
Hepatitis B virus - isolation & purification
Hepatitis B virus - metabolism
Humans
Limit of Detection
Reagent Kits, Diagnostic
Real-Time Polymerase Chain Reaction - methods
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Summary:The detection and quantification of hepatitis B virus (HBV) DNA plays an important role in diagnosing and monitoring HBV infection as well as in assessing the therapeutic response. We compared the analytical performance of a random access, fully automated HBV assay-DxN VERIS Molecular Diagnostics System (Beckman Coulter, Brea, CA, USA)-with that of Abbott RealTime HBV assay (Abbott Laboratories, Des Plaines, IL, USA). The between-day precision of the VERIS assay ranged from 0.92% (mean 4.68 log IU/mL) to 4.15% (mean 2.09 log IU/mL) for pooled sera from HBV patients. HBV DNA levels measured by the VERIS HBV assay correlated with the calculated HBV DNA levels (r²=0.9994;
ISSN:2234-3806
2234-3814
DOI:10.3343/alm.2019.39.1.86