Thermodynamic and kinetic studies sorption of 5-fluorouracil onto single walled carbon nanotubes modified by chitosan

• Published in: The Korean journal of chemical engineering 2019, 36(7), 232, pp.1115-1123
• Main Authors: Karimidost, Samane, Moniri, Elham, Miralinaghi, Mahsasadat
• Format: Article
• Language: English
• Subjects: Adsorption; Biotechnology; Catalysis; Chemistry; Chemistry and Materials Science; Chitosan; Emission analysis; Field emission microscopy; Field emission spectroscopy; Fourier transforms; Industrial Chemistry/Chemical Engineering; Isotherms; Materials Science; Scanning electron microscopy; Separation Technology; Single wall carbon nanotubes; Thermodynamics; Thermogravimetric analysis; X-ray diffraction; 화학공학
• ISSN: 0256-1115; 1975-7220
• DOI: 10.1007/s11814-019-0292-0

Single-walled carbon nanotubes (SWCNTs) were functionalized by chitosan and their application was examined in adsorbing an anti-cancer drug, 5-fluorouracil (5Fu). Surface, physical and morphological characteristics of raw SWCNTs and Chitosan-functionalized SWCNTs (Ch-SWCNTs) were extensively characterized by Fourier transform spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), thermogravimetric analysis (TGA), Brunauer-Emmet-Teller (BET) and X-ray diffraction (XRD). The effects of various variables such as pH, initial drug concentration, temperature, and contact time on adsorption capacity were also investigated. Thermodynamic parameters such as ΔS o , ΔH o , and ΔG o were estimated. Isotherm and kinetic studies of drug adsorption indicated that the adsorption process followed Langmuir isotherm model and pseudo-second-order kinetic, respectively. The maximum adsorption capacity (q m ) of 5Fu on Ch-SWCNTs was 31.77 mg g −1 at 298 K, pH 4.0, and 120 min, which is higher than adsorption capacity of SWCNTs (4.12 mg g −1 ) in the same conditions. The adsorption was spontaneous and exothermic process in nature, with a slight decreasing in entropy.