Conceptual Study for Tissue-Regenerative Biodegradable Magnesium Implant Integrated with Nitric Oxide-Releasing Nanofi bers

• Published in: Metals and materials international 2019, 25(4), , pp.1098-1107
• Main Authors: Jin‑Kyung Jeon(Korea Institute of Science and Technology, Hyunseon Seo(Korea Institute of Science and Technology, Jimin Park(Korea Institute of Science and Technology, Soo Ji Son, Yeong Rim Kim, Eun Shil Kim(Korea Institute of Science and Technology, Jong Woong Park, Woong‑Gyo Jung, Hojeong Jeon(Korea Institute of Science and Technology, Yu‑Chan Kim(Korea Institute of Science and Technology, Hyun‑Kwang Seok(Korea Institute of Science and Technology, Jae Ho Shin, Myoung‑Ryul Ok(Korea Institute of Science and Technology
• Format: Article
• Language: English
• Subjects: 재료공학
• ISSN: 1598-9623; 2005-4149
• DOI: 10.1007/s12540-018-00232-9

The excessive initial corrosion rate of Mg is a critical limitation in the clinical application of biodegradable Mg implantsbecause the device loses its fi xation strength before the fractured bone heals. This study suggests a new approach to overcomethis hurdle by accelerating tissue regeneration instead of delaying the implant biodegradation. As angiogenesis is anessential process in early bone regeneration, a Mg implant coated with electrospun nanofi bers containing nitric oxide (NO),which physiologically promotes angiogenesis, is designed. The integrated device enables adjustable amounts of NO to bestored on the NO donor-conjugated nanofi ber coating, stably delivered, and released to the fractured bone tissue near theimplanted sites. An in vitro corrosion test reveals no adverse eff ect of the released NO on the corrosion behavior of the Mgimplant. Simultaneously, the optimal concentration level of NO released from the implant signifi cantly enhances tube networkformation of human umbilical vein endothelial cells without any cytotoxicity problem. This indicates that angiogenesis canbe accelerated by combining NO-releasing nanofi bers with a Mg implant. With its proven feasibility, the proposed approachcould be a novel solution for the initial stability problem of biodegradable Mg implants, leading to successful bone fi xation. KCI Citation Count: 0