The effect of insulin resistance on prognosis of non-diabetic patients who underwent percutaneous coronary intervention

Insulin resistance is an important risk factor for coronary artery disease. However, there has been no data regarding its clinical effect on the outcomes of percutaneous coronary intervention (PCI) in non-diabetic patients. We analyzed 98 non-diabetic consecutive patients (59+/-11.5 yr, male:female=...

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Published in:Journal of Korean medical science 2006, 21(2), , pp.212-216
Main Authors: Yun, Kyeong Ho, Jeong, Myung Ho, Kim, Kye Hun, Hong, Young Joon, Park, Hyung Wook, Kim, Ju Han, Ahn, Young Keun, Cho, Jeong Gwan, Park, Jong Chun, Kim, Nam Ho, Oh, Seok Kyu, Jeong, Jin Won, Kang, Jung Chaee
Format: Article
Language:English
Subjects:
Aged
Angioplasty, Balloon, Coronary - adverse effects
Coronary Artery Disease - blood
Coronary Artery Disease - physiopathology
Coronary Artery Disease - therapy
Coronary Stenosis - blood
Coronary Stenosis - physiopathology
Coronary Stenosis - therapy
Female
Homeostasis
Humans
Insulin Resistance
Male
Middle Aged
Models, Biological
Original
Prognosis
의학일반
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Summary:Insulin resistance is an important risk factor for coronary artery disease. However, there has been no data regarding its clinical effect on the outcomes of percutaneous coronary intervention (PCI) in non-diabetic patients. We analyzed 98 non-diabetic consecutive patients (59+/-11.5 yr, male:female=63:35) who underwent elective coronary angiography. The patients were divided into two groups: Group I (n=71; the value of HOMA-IR [homeostasis model assessment of insulin resistance] or = 2.6). In-hospital and 30-day major adverse cardiac events (MACE) were compared between the two groups. The concentrations of fasting insulin and triglyceride were significantly higher in Group II than in Group I. Significant correlations were observed between the value of HOMA-IR and body mass index (r=0.489, p or = 2.6 was an independent predictor of MACE. Increased HOMA-IR level is an important prognostic indicator in non-diabetic patients underwent PCI.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2006.21.2.212