Clinical outcomes of patients treated for cervical pregnancy with or without methotrexate

The objective of this study is to describe the clinical outcomes of patients treated for cervical pregnancy with or without methotrexate (MTX) and to evaluate the effects of MTX in the treatment of cervical pregnancy. Between January 1993 and February 2000, 31 patients were diagnosed with cervical p...

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Bibliographic Details
Published in:Journal of Korean medical science 2004, 19(6), , pp.848-852
Main Authors: Kim, Tae Jin, Seong, Seok Ju, Lee, Keum Jung, Lee, Je Hoon, Shin, Joong Sik, Lim, Kyung Taek, Chung, Hwan Wook, Lee, Ki Heon, Park, In Sou, Shim, Jae Uk, Park, Chong Taik
Format: Article
Language:English
Subjects:
Abortifacient Agents, Nonsteroidal - administration & dosage
Dilatation and Curettage - statistics & numerical data
Female
Humans
Incidence
Korea - epidemiology
Methotrexate - administration & dosage
Original
Pregnancy
Pregnancy, Ectopic - drug therapy
Pregnancy, Ectopic - epidemiology
Pregnancy, Ectopic - surgery
Retrospective Studies
Risk Assessment - methods
Risk Factors
Treatment Outcome
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Summary:The objective of this study is to describe the clinical outcomes of patients treated for cervical pregnancy with or without methotrexate (MTX) and to evaluate the effects of MTX in the treatment of cervical pregnancy. Between January 1993 and February 2000, 31 patients were diagnosed with cervical pregnancy. Twenty-two patients were treated with MTX chemotherapy and nine patients were treated with surgical procedures without MTX treatment. In the non-MTX treatment group, three patients underwent total abdominal hysterectomy, five required adjuvant procedures to control the bleeding during dilatation and curettage (D&C) and only one patient was treated with a simple D&C. In the MTX treatment group, fourteen (63.6%) patients were treated with only MTX and eight (36.4%) cases underwent concomitant procedures (simple curettage, curettage and Foley catheter tamponade, cervical cerclage, ligation of the descending branches of uterine arteries, or ligation of hypogastric arteries). The uterus was preserved in all cases and three women delivered healthy babies in their subsequent pregnancy. In conclusion, early diagnosis, appropriate MTX regimen in combination of necessary adjuvant conservative procedures could contribute to successful treatment with preservation of the uterus and future reproductive ability.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2004.19.6.848