Correlation of serum S100B levels with brain magnetic resonance imaging abnormalities in children with status epilepticus

• Published in: Clinical and experimental pediatrics 2019, 62(7), , pp.281-285
• Main Authors: Gunawan, Prastiya Indra, Saharso, Darto, Sari, Dian Purnama
• Format: Article
• Language: English
• Subjects: Biomarkers; Brain research; Child; Consciousness; Consent; Convulsions & seizures; Head injuries; Hypoxia; Ischemia; Magnetic resonance imaging; Nervous system; Original; Patients; Plasma; Proteins; S100B; Software; Statistical analysis; Status epilepticus; Trauma; 소아과학
• ISSN: 1738-1061; 2092-7258; 2713-4148
• DOI: 10.3345/kjp.2018.07017

To evaluate the association between elevated S100B levels with brain tissue damage seen in abnormalities of head magnetic resonance imaging (MRI; diffusion tensor imaging [DTI] sequence) in patients with status epilepticus (SE). An analytical observational study was conducted in children hospitalized at Dr Soetomo Hospital, Surabaya, from July to December 2016. The patients were divided into 2 groups: SE included all children with a history of SE; control included all children with febrile seizure. Blood samples of patients were drawn within 24 hours after admission. SE patients also underwent cranial MRI with additional DTI sequencing. The Mann-Whitney test and Spearman test were used for statistical analysis. Fifty-three patients were enrolled the study. In the 24 children with SE who met the inclusion criteria, serum S100B and cranial MRI findings were assessed. Twenty-two children admitted with febrile seizures became the control group. Most patients were male (66.7%); the mean age was 35.8 months (standard deviation, 31.09). Mean S100B values of the SE group (3.430±0.141 μg/L) and the control group (2.998±0.572 μg/L) were significantly different (P