Pleural fluid characteristics of pleuropulmonary paragonimiasis masquerading as pleural tuberculosis

• Published in: The Korean journal of internal medicine 2015, 30(1), , pp.56-61
• Main Authors: Hwang, Ki-Eun, Song, Hyo-Yeop, Jung, Jae-Wan, Oh, Su-Jin, Yoon, Kwon-Ha, Park, Do-Sim, Jeong, Eun-Taik, Kim, Hak-Ryul
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Animals; Biomarkers - analysis; Child; Child, Preschool; Diagnosis, Differential; Enzyme-Linked Immunosorbent Assay; Eosinophilia - diagnosis; Eosinophilia - parasitology; Female; Glucose - analysis; Humans; L-Lactate Dehydrogenase - analysis; Lung Diseases, Parasitic - diagnosis; Lung Diseases, Parasitic - diagnostic imaging; Lung Diseases, Parasitic - metabolism; Lung Diseases, Parasitic - parasitology; Male; Middle Aged; Original; Paracentesis; Paragonimiasis - diagnosis; Paragonimiasis - diagnostic imaging; Paragonimiasis - metabolism; Paragonimiasis - parasitology; Paragonimus westermani - isolation & purification; Pleural Effusion - diagnosis; Pleural Effusion - diagnostic imaging; Pleural Effusion - metabolism; Pleural Effusion - parasitology; Predictive Value of Tests; Retrospective Studies; Tomography, X-Ray Computed; Tuberculosis, Pleural - diagnosis; Young Adult; 내과학
• ISSN: 1226-3303; 2005-6648
• DOI: 10.3904/kjim.2015.30.1.56

Pleuropulmonary paragonimiasis produces no specific symptoms or radiologic findings, allowing for the possibility of misdiagnosis. We evaluated the specific clinical and pleural fluid features of pleuropulmonary paragonimiasis masquerading as pleural tuberculosis. We retrospectively analyzed the clinical and radiologic characteristics of 20 patients diagnosed with pleuropulmonary paragonimiasis between 2001 and 2011. In total, 17 patients presented with respiratory symptoms, including dyspnea (30%), hemoptysis (20%), cough (20%), and pleuritic chest pain (15%). Chest radiographs revealed intrapulmonary parenchymal lesions, including air-space consolidation (30%), nodular opacities (20%), cystic lesions (15%), ground-glass opacities (10%), and pneumothorax (5%). A pleural fluid examination revealed eosinophilia, low glucose levels, and high lactate dehydrogenase (LDH) levels in 87%, 76%, and 88% of the patients, respectively. These traits helped to distinguish pleuropulmonary paragonimiasis from other pleural diseases such as parapneumonic effusion, malignancy, and pleural tuberculosis. Pleuropulmonary paragonimiasis is often initially misdiagnosed as other pleural diseases. Therefore, it is important to establish the correct diagnosis. In patients with unexplained pleural effusion living in paragonimiasis-endemic areas, pleural fluid obtained by thoracentesis should be examined to distinguish pleuropulmonary paragonimiasis. When marked eosinophilia, high LDH levels, and low glucose levels are identified in pleural fluid, physicians could consider a diagnosis of pleuropulmonary paragonimiasis.