Impact of retrotransposons in pluripotent stem cells

Retrotransposons, which constitute approximately 40% of the human genome, have the capacity to 'jump' across the genome. Their mobility contributes to oncogenesis, evolution, and genomic plasticity of the host genome. Induced pluripotent stem cells as well as embryonic stem cells are more...

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Bibliographic Details
Published in:Molecules and cells 2012, 34(6), , pp.509-516
Main Authors: Tanaka, Yoshiaki, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA, Chung, Leeyup, Duke University Medical Center, Durham, NC, USA, Park, I.H., Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA
Format: Article
Language:English
Subjects:
Alu
Alu Elements
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Cell Biology
Cell Differentiation
Embryonic Stem Cells - metabolism
GENOMAS
GENOME
Genome, Human
GENOMES
Humans
Induced Pluripotent Stem Cells - metabolism
Life Sciences
LTR retrotransposon
Minireview
pluripotent stem cell
Pluripotent Stem Cells - metabolism
Retroelements
SVA
생물학
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Summary:Retrotransposons, which constitute approximately 40% of the human genome, have the capacity to 'jump' across the genome. Their mobility contributes to oncogenesis, evolution, and genomic plasticity of the host genome. Induced pluripotent stem cells as well as embryonic stem cells are more susceptible than differentiated cells to genomic aberrations including insertion, deletion and duplication. Recent studies have revealed specific behaviors of retrotransposons in pluripotent cells. Here, we review recent progress in understanding retrotransposons and provide a perspective on the relationship between retrotransposons and genomic variation in pluripotent stem cells.
ISSN:1016-8478
0219-1032
DOI:10.1007/s10059-012-0242-8