Regulation of Reactive Oxygen Species Generation in Cell Signaling

Reactive oxygen species (ROS) including superoxide anion and hydrogen peroxide (H₂O₂) are thought to be byproducts of aerobic respiration with damaging effects on DNA, protein, and lipid. A growing body of evidence indicates, however, that ROS are involved in the maintenance of redox homeostasis and...

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Bibliographic Details
Published in:Molecules and cells 2011, 32(6), , pp.491-509
Main Authors: Bae, Y.S., Ewha Womans University, Seoul, Republic of Korea, Oh, H.J., Ewha Womans University, Seoul, Republic of Korea, Rhee, S.G., Ewha Womans University, Seoul, Republic of Korea, Yoo, Y.D., Korea University, Seoul, Republic of Korea
Format: Article
Language:English
Subjects:
APOPTOSE
APOPTOSIS
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Cell Biology
cell signaling
CITOCROMO P450
CYTOCHROME P450
ESPECIES DE OXIGENO REACTIVO
Life Sciences
Minireview
MITOCHONDRIA
MITOCHONDRIE
MITOCONDRIA
NADPH oxidase
REACTIVE OXYGEN SPECIES
생물학
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Summary:Reactive oxygen species (ROS) including superoxide anion and hydrogen peroxide (H₂O₂) are thought to be byproducts of aerobic respiration with damaging effects on DNA, protein, and lipid. A growing body of evidence indicates, however, that ROS are involved in the maintenance of redox homeostasis and various cellular signaling pathways. ROS are generated from diverse sources including mitochondrial respiratory chain, enzymatic activation of cytochrome p450, and NADPH oxidases further suggesting involvement in a complex array of cellular processes. This review summarizes the production and function of ROS. In particular, how cytosolic and membrane proteins regulate ROS generation for intracellular redox signaling will be detailed.
ISSN:1016-8478
0219-1032
DOI:10.1007/s10059-011-0276-3