Synthesis of new phosphate derivative of benzothiazole and its inhibiting effect on two series of human neuroblastoma cell growth

The sodium salt of di ((1-hydroxy-2-benzothiazolium-1-yl) ethyliden-1,1-H-bisphosphonic acid) orthophosphate was synthesized and its toxicity and viability effects screened on two different human neuroblastoma cell lines. This novel derivative of benzothiazole provides a new compound in connection w...

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Bibliographic Details
Published in:The Korean journal of chemical engineering 2013, 30(3), 156, pp.675-679
Main Authors: Nezhati, Mahshid Nikpour, Riazi, Gholam Hossein, Panahi, Homayon Ahmad, Moniri, Elham, Rajabi, Nasir Ahmad, Sadughi, Mohammad Mehdi, Zaker, Natasha Rahmani, Ardekani, Robab, Kooshkestani, Reihaneh
Format: Article
Language:English
Subjects:
Biotechnology
Catalysis
Chemistry
Chemistry and Materials Science
Industrial Chemistry/Chemical Engineering
Materials Science
화학공학
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Summary:The sodium salt of di ((1-hydroxy-2-benzothiazolium-1-yl) ethyliden-1,1-H-bisphosphonic acid) orthophosphate was synthesized and its toxicity and viability effects screened on two different human neuroblastoma cell lines. This novel derivative of benzothiazole provides a new compound in connection with research and therapeutic application for tumor cell growth inhibition. Benzothiazole was alkylated in reaction with bromoacetic acid and then converted to its H-bisphosphonic acid derivative in presence of H 3 PO 3 /POCl 3 . The procedure led to formation of two molecules of corresponding H-bisphosphonic acid which attached together via a phosphate bridge. The investigated compound exhibits activities (IC 50 value) ranging from 14–23 μM (corresponding to human neuroblastoma SK-BE (2) and SK-NM-C cells).
ISSN:0256-1115
1975-7220
DOI:10.1007/s11814-012-0191-0