Separation of the Enantiomers of β-Blockers Using Brush Type Chiral Stationary Phase Derived from Conformationally Rigid α-Amino β-Lactam

A brush type chiral stationary phase (CSP 2) derived from α-amino β-lactam was prepared for the separation of the enantiomers of β-blockers. Compared to the CSP derived from α-amino phosphonate (CSP 1), in general, the conformationally rigid CSP 2 showed greater scope and much enhanced enantioselect...

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Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2010, 31(3), , pp.620-623
Main Authors: Pirkle, William H., Lee, Won-Jae
Format: Article
Language:English
Subjects:
화학
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Summary:A brush type chiral stationary phase (CSP 2) derived from α-amino β-lactam was prepared for the separation of the enantiomers of β-blockers. Compared to the CSP derived from α-amino phosphonate (CSP 1), in general, the conformationally rigid CSP 2 showed greater scope and much enhanced enantioselectivity for the resolution of β-blockers. The effect of various salt additives on enantioseparation of β-blockers in the mobile phase was investigated. The unusual effect of temperature on the chromatographic behaviors was observed on CSP 2. It also afforded appreciable increases in enantioselectivity without significantly affecting resolution, as the column temperature was reduced. KCI Citation Count: 10
ISSN:0253-2964
1229-5949
DOI:10.5012/bkcs.2010.31.03.620