Immunological activities of cationic methylan derivatives

Methylan polysaccharide was aminated to add dialkylaminoethyl and free amino groups at hydroxyl sites in the methylan backbone, and these derivatives were quaternized to produce pH-independent cationic polyelectrolytes. The immunological activities of the resulting methylan derivatives were investig...

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Bibliographic Details
Published in:Applied biological chemistry 2014, 57(3), , pp.319-321
Main Authors: Lee, Jung-Kul, Kim, In-Won, Kim, Tae-Su, Choi, Joon-Ho, Kim, Jung-Hoe, Park, Si-Hyung
Format: Article
Language:English
Subjects:
Amino groups
Applied Microbiology
Biological Techniques
Bioorganic Chemistry
Cations
Chemistry
Chemistry and Materials Science
Classical pathway
Complement system
Derivatives
Electrostatic properties
Immunology
Polyelectrolytes
Polysaccharides
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Summary:Methylan polysaccharide was aminated to add dialkylaminoethyl and free amino groups at hydroxyl sites in the methylan backbone, and these derivatives were quaternized to produce pH-independent cationic polyelectrolytes. The immunological activities of the resulting methylan derivatives were investigated. Diethylaminoethyl (DEAE)-methylan derivatives inhibited the classical pathway of the complement system in a dose-dependent way. Quaternized DEAE-methylan exhibited the highest anticomplementary activities among the all derivatives. Anticomplementary activities increased significantly as the cationic charge of the methylan derivatives increased via aminoderivatization followed by quaternization, indicating that there is an electrostatic interaction between the methylan derivatives and the negatively charged functional residues on the cell.
ISSN:1738-2203
2468-0834
2234-344X
2468-0842
DOI:10.1007/s13765-013-4312-1