In vitro and in vivo effects of polysaccharides isolated from Korean persimmon vinegar on intestinal immunity

The in vitro and in vivo effects of crude polysaccharide isolated from Korean persimmon vinegar (KPV-0) on the intestinal immunostimulation were examined. KPV-0 was not cytotoxic to intestinal epithelial Caco-2 cells and could be transported through a Caco-2 cell monolayer in an in vitro coculture s...

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Bibliographic Details
Published in:Applied biological chemistry 2015, 58(6), , pp.867-876
Main Authors: Lee Min Young, Kim, Hoon, Shin, Kwang Soon
Format: Article
Language:English
Subjects:
Colony-stimulating factor
Cytokines
Cytotoxicity
Growth factors
Immune system
Immunoglobulin A
Immunostimulation
In vivo methods and tests
Interleukin 6
Intestine
Leukocytes (granulocytic)
Macrophages
Oral administration
Persimmons
Polysaccharides
Saccharides
Transforming growth factor-b1
Vinegar
농학
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Summary:The in vitro and in vivo effects of crude polysaccharide isolated from Korean persimmon vinegar (KPV-0) on the intestinal immunostimulation were examined. KPV-0 was not cytotoxic to intestinal epithelial Caco-2 cells and could be transported through a Caco-2 cell monolayer in an in vitro coculture system. For and in vitro experiment, KPV-0 treatment significantly increased IgA production by Peyer’s patch (PP) cells and triggered an increase in transforming growth factor (TGF)-β1 and interleukin (IL)-6 levels. To investigate the in vivo effects of KPV-0 treatment, KPV-0 was administered to mice orally at different doses for 20 days. Oral administration of KPV-0-induced IgA and cytokines (IL-6, granulocyte macrophage-colony-stimulating factor, and TGF-β) production by PP cells and significantly increased the IgA levels in intestinal fluids and feces. These results suggested that the polysaccharides isolated from persimmon vinegar appear to modulate the intestinal immune system and could be beneficial to human health.
ISSN:2468-0834
2468-0842
DOI:10.1007/s13765-015-0117-8