Long-Term Clinical Effects of Carotid Intraplaque Neovascularization in Patients with Coronary Artery Disease

Objective To investigate the predictive value of intraplaque neovascularization (IPN) for cardiovascular outcomes. Materials and Methods We evaluated 217 patients with coronary artery disease (CAD) (158 men; mean age, 68 ± 10 years) with a maximal carotid plaque thickness ≥ 1.5 mm for the presence o...

Full description

Saved in:
Bibliographic Details
Published in:Korean journal of radiology 2020, 21(7), , pp.900-907
Main Authors: Chung, Hyemoon, Kim, Bu Yong, Kim, Hyun Soo, Kim, Hyung Oh, Lee, Jung Myung, Woo, Jong Shin, Kim, Jin Bae, Kim, Woo-Shik, Kim, Kwon Sam, Kim, Weon
Format: Article
Language:English
Subjects:
Angina pectoris
Automation
Blood pressure
Cardiovascular disease
Cardiovascular Imaging
Carotid arteries
Coronary vessels
Medical records
Patients
Regression analysis
Transient ischemic attack
Ultrasonic imaging
Vein & artery diseases
Velocity
방사선과학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective To investigate the predictive value of intraplaque neovascularization (IPN) for cardiovascular outcomes. Materials and Methods We evaluated 217 patients with coronary artery disease (CAD) (158 men; mean age, 68 ± 10 years) with a maximal carotid plaque thickness ≥ 1.5 mm for the presence of IPN using contrast-enhanced ultrasonography. We compared patients with (n = 116) and without (n = 101) IPN during the follow-up period and investigated the predictors of major adverse cardiovascular events (MACE), including cardiac death, myocardial infarction, coronary artery revascularization, and transient ischemic accident/stroke. Results During the mean follow-up period of 995 ± 610 days, the MACE rate was 6% (13/217). Patients with IPN had a higher maximal thickness than those without IPN (2.86 ± 1.01 vs. 2.61 ± 0.84 mm, p = 0.046). Common carotid artery-peak systolic velocity, left ventricular mass index (LVMI), and ventricular-vascular coupling index were significantly correlated with MACE. However, on multivariate Cox regression analysis, increased LVMI was independently related to MACE (p Conclusion The presence of IPN was related to a higher plaque thickness but could not predict cardiovascular outcomes better than conventional clinical factors in patients with CAD.
ISSN:1229-6929
2005-8330
DOI:10.3348/kjr.2019.0550