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Formulation of highly purified fenugreek gum based silica lipid drug delivery system for simvastatin with enhanced dissolution rate and in vitro characterization
In current study, highly purified fenugreek gum (HPFG) isolated by patented method explored as emulsifier and hydrophilic solid carrier in drug delivery system. Anti-hyperlipidemic drug simvastatin (SIM) was selected as drug model for the study as it is associated with poorly water solubility and lo...
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| Published in: | Journal of pharmaceutical investigation 2013, 43(5), , pp.363-373 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c2364-d927fad06e1bf805b5bf7b0b84ae17a3153197dbd3bf9f649e70a235699d2c5f3 |
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| cites | cdi_FETCH-LOGICAL-c2364-d927fad06e1bf805b5bf7b0b84ae17a3153197dbd3bf9f649e70a235699d2c5f3 |
| container_end_page | 373 |
| container_issue | 5 |
| container_start_page | 363 |
| container_title | Journal of pharmaceutical investigation |
| container_volume | 43 |
| creator | Sav, Ajay Kumar Ali, Meer Tarique Fule, Ritesh Amol Amin, Purnima Dhanraj |
| description | In current study, highly purified fenugreek gum (HPFG) isolated by patented method explored as emulsifier and hydrophilic solid carrier in drug delivery system. Anti-hyperlipidemic drug simvastatin (SIM) was selected as drug model for the study as it is associated with poorly water solubility and low bioavailability problems ( |
| doi_str_mv | 10.1007/s40005-013-0081-4 |
| format | article |
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®
MCM (10 %) as lipid phase, 0.6 % HPFG as emulsifier and HPFG 2.5 %, different grades colloidal silica (7.5 %) (Aerosil
®
300 Pharma, Aerosil
®
380 Pharma and Aeroperl
®
300 Pharma) as hydrophilic solid carriers was developed. The optimized HPFG-based silica lipid systems were characterized for physical characteristics like flow ability, compressibility, redispersiblity, solubility and in vitro drug release using USP apparatus II in pH 6.8 phosphate buffer. The system was also characterized for Fourier transform infrared spectroscopy, powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). The developed formulation was found to have excellent flow property, readily redispersiblity, better aqueous solubility and showed 3–4-fold increase in dissolution rate as compared to plain drug and marketed formulation (Simlo
®
10). Transition of crystalline drug to amorphous state was confirmed by DSC, PXRD and SEM studies. Enhanced dissolution rate and solubility possibly attributed to improved wetting, amorphous drug state and facilitated diffusion from lipid-based system. Thus developed HPFG-based silica lipid system provides an alternative means for SIM with enhanced dissolution rate and stability in oral solid dosage form.</description><identifier>ISSN: 2093-5552</identifier><identifier>EISSN: 2093-6214</identifier><identifier>DOI: 10.1007/s40005-013-0081-4</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Research Article ; 약학</subject><ispartof>Journal of Pharmaceutical Investigation, 2013, 43(5), , pp.363-373</ispartof><rights>The Korean Society of Pharmaceutical Sciences and Technology 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2364-d927fad06e1bf805b5bf7b0b84ae17a3153197dbd3bf9f649e70a235699d2c5f3</citedby><cites>FETCH-LOGICAL-c2364-d927fad06e1bf805b5bf7b0b84ae17a3153197dbd3bf9f649e70a235699d2c5f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001812448$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Sav, Ajay Kumar</creatorcontrib><creatorcontrib>Ali, Meer Tarique</creatorcontrib><creatorcontrib>Fule, Ritesh Amol</creatorcontrib><creatorcontrib>Amin, Purnima Dhanraj</creatorcontrib><title>Formulation of highly purified fenugreek gum based silica lipid drug delivery system for simvastatin with enhanced dissolution rate and in vitro characterization</title><title>Journal of pharmaceutical investigation</title><addtitle>Journal of Pharmaceutical Investigation</addtitle><description>In current study, highly purified fenugreek gum (HPFG) isolated by patented method explored as emulsifier and hydrophilic solid carrier in drug delivery system. Anti-hyperlipidemic drug simvastatin (SIM) was selected as drug model for the study as it is associated with poorly water solubility and low bioavailability problems (<5 %). A suitable HPFG-based silica lipid system composed of SIM (1.5 %), medium chain triglyceride Capmul
®
MCM (10 %) as lipid phase, 0.6 % HPFG as emulsifier and HPFG 2.5 %, different grades colloidal silica (7.5 %) (Aerosil
®
300 Pharma, Aerosil
®
380 Pharma and Aeroperl
®
300 Pharma) as hydrophilic solid carriers was developed. The optimized HPFG-based silica lipid systems were characterized for physical characteristics like flow ability, compressibility, redispersiblity, solubility and in vitro drug release using USP apparatus II in pH 6.8 phosphate buffer. The system was also characterized for Fourier transform infrared spectroscopy, powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). The developed formulation was found to have excellent flow property, readily redispersiblity, better aqueous solubility and showed 3–4-fold increase in dissolution rate as compared to plain drug and marketed formulation (Simlo
®
10). Transition of crystalline drug to amorphous state was confirmed by DSC, PXRD and SEM studies. Enhanced dissolution rate and solubility possibly attributed to improved wetting, amorphous drug state and facilitated diffusion from lipid-based system. Thus developed HPFG-based silica lipid system provides an alternative means for SIM with enhanced dissolution rate and stability in oral solid dosage form.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Research Article</subject><subject>약학</subject><issn>2093-5552</issn><issn>2093-6214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kc9KxDAQxosoKLoP4C1HL9VJ27TNUcQ_C4Igeg5pk7TZbZNl0q6sb-Obmt317GmG4fd9M8OXJNcUbilAdRcKAGAp0DwFqGlanCQXGfA8LTNanP71jLHsPFmEsII9XdK65hfJz5PHcR7kZL0j3pDedv2wI5sZrbFaEaPd3KHWa9LNI2lkiLNgB9tKMtiNVUTh3BGlB7vVuCNhFyY9EuMxUuNWhik6O_Jlp55o10vXRr2yIfhhPqxEOWkinSKR2toJPWl7ibKdNNrvw1VXyZmRQ9CLv3qZfD49fjy8pK9vz8uH-9e0zfKySBXPKiMVlJo2pgbWsMZUDTR1ITWtZE5ZTnmlGpU3hpuy4LoCmeWs5FxlLTP5ZXJz9HVoxLq1wkt7qJ0XaxT37x9LwUuoSxpRekRb9CGgNmKDdpS4ExTEPhFxTETERMQ-EVFETXbUhMi6TqNY-Rld_Ogf0S9G7pKU</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Sav, Ajay Kumar</creator><creator>Ali, Meer Tarique</creator><creator>Fule, Ritesh Amol</creator><creator>Amin, Purnima Dhanraj</creator><general>Springer Netherlands</general><general>한국약제학회</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ACYCR</scope></search><sort><creationdate>201310</creationdate><title>Formulation of highly purified fenugreek gum based silica lipid drug delivery system for simvastatin with enhanced dissolution rate and in vitro characterization</title><author>Sav, Ajay Kumar ; Ali, Meer Tarique ; Fule, Ritesh Amol ; Amin, Purnima Dhanraj</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2364-d927fad06e1bf805b5bf7b0b84ae17a3153197dbd3bf9f649e70a235699d2c5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Research Article</topic><topic>약학</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sav, Ajay Kumar</creatorcontrib><creatorcontrib>Ali, Meer Tarique</creatorcontrib><creatorcontrib>Fule, Ritesh Amol</creatorcontrib><creatorcontrib>Amin, Purnima Dhanraj</creatorcontrib><collection>CrossRef</collection><collection>Korean Citation Index</collection><jtitle>Journal of pharmaceutical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sav, Ajay Kumar</au><au>Ali, Meer Tarique</au><au>Fule, Ritesh Amol</au><au>Amin, Purnima Dhanraj</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Formulation of highly purified fenugreek gum based silica lipid drug delivery system for simvastatin with enhanced dissolution rate and in vitro characterization</atitle><jtitle>Journal of pharmaceutical investigation</jtitle><stitle>Journal of Pharmaceutical Investigation</stitle><date>2013-10</date><risdate>2013</risdate><volume>43</volume><issue>5</issue><spage>363</spage><epage>373</epage><pages>363-373</pages><issn>2093-5552</issn><eissn>2093-6214</eissn><abstract>In current study, highly purified fenugreek gum (HPFG) isolated by patented method explored as emulsifier and hydrophilic solid carrier in drug delivery system. Anti-hyperlipidemic drug simvastatin (SIM) was selected as drug model for the study as it is associated with poorly water solubility and low bioavailability problems (<5 %). A suitable HPFG-based silica lipid system composed of SIM (1.5 %), medium chain triglyceride Capmul
®
MCM (10 %) as lipid phase, 0.6 % HPFG as emulsifier and HPFG 2.5 %, different grades colloidal silica (7.5 %) (Aerosil
®
300 Pharma, Aerosil
®
380 Pharma and Aeroperl
®
300 Pharma) as hydrophilic solid carriers was developed. The optimized HPFG-based silica lipid systems were characterized for physical characteristics like flow ability, compressibility, redispersiblity, solubility and in vitro drug release using USP apparatus II in pH 6.8 phosphate buffer. The system was also characterized for Fourier transform infrared spectroscopy, powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). The developed formulation was found to have excellent flow property, readily redispersiblity, better aqueous solubility and showed 3–4-fold increase in dissolution rate as compared to plain drug and marketed formulation (Simlo
®
10). Transition of crystalline drug to amorphous state was confirmed by DSC, PXRD and SEM studies. Enhanced dissolution rate and solubility possibly attributed to improved wetting, amorphous drug state and facilitated diffusion from lipid-based system. Thus developed HPFG-based silica lipid system provides an alternative means for SIM with enhanced dissolution rate and stability in oral solid dosage form.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s40005-013-0081-4</doi><tpages>11</tpages></addata></record> |
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| ispartof | Journal of Pharmaceutical Investigation, 2013, 43(5), , pp.363-373 |
| issn | 2093-5552 2093-6214 |
| language | eng |
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| source | Springer Nature |
| subjects | Biomedical and Life Sciences Biomedicine Research Article 약학 |
| title | Formulation of highly purified fenugreek gum based silica lipid drug delivery system for simvastatin with enhanced dissolution rate and in vitro characterization |
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