Extracellular Vesicles from Korean Codium fragile and Sargassum fusiforme Negatively Regulate Melanin Synthesis

Although various marine ingredients have been exploited for the development of cosmetic products, no previous study has examined the potential of seaweed extracellular vesicles (EV) in such applications. Our results revealed that EV from and effectively decreased α-MSH-mediated melanin synthesis in...

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Bibliographic Details
Published in:Molecules and cells 2021, 44(10), , pp.736-745
Main Authors: Jang, Bohee, Chung, Heesung, Jung, Hyejung, Song, Hyun-Kuk, Park, Eunhye, Choi, Hack Sun, Jung, Kyuhyun, Choe, Han, Yang, Sanghwa, Oh, Eok-Soo
Format: Article
Language:English
Subjects:
Animals
Cell Line, Tumor
Epidermis - drug effects
Epidermis - metabolism
Extracellular Vesicles - metabolism
Humans
Melanins - biosynthesis
Melanoma - metabolism
Sargassum - chemistry
Seaweed - chemistry
Skin - drug effects
Skin - metabolism
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Summary:Although various marine ingredients have been exploited for the development of cosmetic products, no previous study has examined the potential of seaweed extracellular vesicles (EV) in such applications. Our results revealed that EV from and effectively decreased α-MSH-mediated melanin synthesis in MNT-1 human melanoma cells, associated with downregulation of MITF (microphthalmia-associated transcription factor), tyrosinase and TRP1 (tyrosinase-related proteins 1). The most effective inhibitory concentrations of EV were 250 μg/ml for and 25 μg/ml for , without affecting the viability of MNT-1 cells. Both EV reduced melanin synthesis in the epidermal basal layer of a three-dimensional model of human epidermis. Moreover, the application of the prototype cream containing EV (final 5 μg/ml) yielded 1.31% improvement in skin brightness in a clinical trial. Together, these results suggest that EV from and reduce melanin synthesis and may be potential therapeutic and/or supplementary whitening agents.
ISSN:1016-8478
0219-1032
DOI:10.14348/MOLCELLS.2021.2167