Electrochemical evaluation of naproxen through Au@f-CNT/GO nanocomposite in environmental water and biological samples

• Published in: Journal of industrial and engineering chemistry (Seoul, Korea) 2021, 104(0), , pp.32-42
• Main Authors: Alagumalai, Krishnapandi, Musuvadhi Babulal, Sivakumar, Chen, Shen-Ming, Shanmugam, Ragurethinam, Yesuraj, Johnbosco
• Format: Article
• Language: English
• Subjects: Gold nanoparticles; Graphene oxide; Naproxen; Oxidized single-walled carbon nanotube; Voltammetry; 화학공학
• ISSN: 1226-086X; 1876-794X
• DOI: 10.1016/j.jiec.2021.08.009

An electrochemical sensor based on Au@f-CNT/GO/GCE for detection of Naproxen. [Display omitted] The cytotoxic dosage of exposed drug waste is frequently discharging on aquatic surfaces via wastewater treatment plants and pharma industries. Early detection of these drug wastes with a reliable and accurate are in great need. In this report, a noble metal effectively doped on oxidized one-dimensional (1D) single-walled carbon nanotube and abundant oxygen functional groups presenting two-dimensional (2D) graphene oxide on its surface, and hydrophobic cavities are the promising selector towards electrochemical oxidation of Naproxen (NPZ). A hybrid nanocomposite Au@f-CNT/GO was engineered by the ultrasound-assist sonication method and employed for the ultra-quantification of the therapeutic drug NPZ. In addition, various physicochemical and analytical techniques were utilized to confirm the successful formation of composite and principal detection of NPZ. Au@f-CNT/GO fabricated glassy carbon electrode exhibits a low resistance and higher electrocatalytic activity toward NPZ sensing. In addition, under the optimized condition, the sensor demonstrates an acceptable linear range of 100 nM − 15.6 µM, a lower limit of detection of 14 nM (S/N = 3), and higher sensitivity of 1.7484 μA μM−1 cm2. Furthermore, the proposed sensor has high selectivity, stability, reproducibility, and repeatability. Moreover, real sample analysis shows appreciable recovery results of 96 to 99% which strongly suggests that the proposed sensor has potential applicability for the sensitive detection of NPZ in the various water and biological samples.