Challenges and Opportunities for Effective Cancer Immunotherapies

Anti-cancer immunotherapies have generated spectacular outcomes in the clinical environment and changed treatment schemes for cancer patients. Adoptive cell therapies (ACTs), including using autologous tumor-infiltrating lymphocytes and chimeric antigen receptor (CAR) T cells, and checkpoint blockad...

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Bibliographic Details
Format:	Book
Language:	English
Subjects:	adipose tissue-derived stem cells (ADSCs) adoptive cell therapy adoptive cell transfer animal model anti-cancer therapies anti-tumor immunity antibody therapy antigen processing and presentation Axl B cell biomimicry breast cancer cancer cancer immunotherapy CAR T cell therapy CAR T cells CD19 CD3-bispecific antibody CD44 CD8 coreceptor cell cycle cervical cancer checkpoint inhibitors chemotherapy chimeric antigen receptor chimeric antigen receptor (CAR) T cell (CAR-T) clinical trial clinical trials combination therapy convergent evolution cross-priming CRS dendritic cell dendritic cell vaccination dendritic cells endodomain Flt3 Flt3L GBM gene therapy glioblastoma HER2-positive histon (de)acetylation IL-12 family cytokines immune cell immune checkpoint blockade immune checkpoint inhibitor immune checkpoint inhibitors immune checkpoint molecules immune evasion immune response immuno-oncology immunocyte membrane-coated nanoparticles immunogenicity immunotherapy individualized multimodal immunotherapy interleukin-15 intratumoural local ablation therapies macrophage major histocompatibility complex Medicine and Nursing melanoma memory T cell MerTK mesenchymal stem cells metabolic reprogramming microenvironment mitochondria modulated electrohyperthermia monoclonal antibodies monoclonal antibody murine myxoma virus n/a natural killer near infrared photoimmunotherapy newcastle disease virus NK cell immunosurveillance NK cells NKG2D NKG2D ligands NKG2D receptor nonreplicating adenovirus vector oligomerization on-target off-tumor toxicity oncolytic virotherapy oncolytic virus pancreatic ductal adenocarcinoma pancreatic tumor pattern-recognition receptors PD-1 PD-1/PD-L1 pembrolizumab preclinical protein kinase inhibitors radiotherapy recurrence ROPN1 ROPN1B Ropporin-1 Ropporin-1B routes of delivery signal transduction signaling kinetics small molecule inhibitors solid tumors STAT T cell T cell metabolism T cell receptor T lymphocyte T-cell co-stimulation T-cell engager TAM receptors targeted therapy TNFα toll-like receptors toxicity tumor microenvironment tumor-associated antigens tumor-infiltrating lymphocytes tumor-specific antigen tumour antigens tumour microenvironment virus coated with cancer cell membrane viruses
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