Controlled Generation of Singlet Oxygen in Living Cells with Tunable Ratios of the Photochromic Switch in Metal-Organic Frameworks

Development of a photosensitizing system that can reversibly control the generation of singlet oxygen (1O2) is of great interest for photodynamic therapy (PDT). Recently several photosensitizer–photochromic‐switch dyads were reported as a potential means of the 1O2 control in PDT. However, the deliv...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2016-06, Vol.55 (25), p.7188-7193
Main Authors: Park, Jihye, Jiang, Qin, Feng, Dawei, Zhou, Hong-Cai
Format: Article
Language:English
Subjects:
Cells (biology)
Control systems
Effectiveness
Energy transfer
Functional anatomy
membrane, carbon capture, materials and chemistry by design, synthesis (novel materials), synthesis (self-assembly), synthesis (scalable processing)
Metal-organic frameworks
Metals
Nanoparticles
Nanostructure
Optimization
Oxygen
Photochromism
Photodynamic therapy
Photosensitization
Placement
Singlet oxygen
Tuning
Zirconium
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Summary:Development of a photosensitizing system that can reversibly control the generation of singlet oxygen (1O2) is of great interest for photodynamic therapy (PDT). Recently several photosensitizer–photochromic‐switch dyads were reported as a potential means of the 1O2 control in PDT. However, the delivery of such a homogeneous molecular dyad as designed (e.g., optimal molar ratio) is extremely challenging in living systems. Herein we show a Zr‐MOF nanoplatform, demonstrating energy transfer‐based 1O2 controlled PDT. Our strategy allows for tuning the ratios between photosensitizer and the switch molecule, enabling maximum control of 1O2 generation. Meanwhile, the MOF provides proximal placement of the functional entities for efficient intermolecular energy transfer. As a result, the MOF nanoparticle formulation showed enhanced PDT efficacy with superior 1O2 control compared to that of homogeneous molecular analogues. A switch inside: In situ incorporation of a photosensitizing system into MOF nanoparticles to control 1O2 generation is possible using a tunable ratio of a photochromic switch. The MOF formulation allows enhanced in vitro photodynamic therapy (PDT) efficacy with a superior control of 1O2 production compared to a simple mixture of the dyad.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201602417