Structural and functional insights into the role of BamD and BamE within the β-barrel assembly machinery in Neisseria gonorrhoeae

The β-barrel assembly machinery (BAM) is a conserved multicomponent protein complex responsible for the biogenesis of β-barrel outer membrane proteins (OMPs) in Gram-negative bacteria. Given its role in the production of OMPs for survival and pathogenesis, BAM represents an attractive target for the...

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Bibliographic Details
Published in:The Journal of biological chemistry 2018-01, Vol.293 (4), p.1106-1119
Main Authors: Sikora, Aleksandra E., Wierzbicki, Igor H., Zielke, Ryszard A., Ryner, Rachael F., Korotkov, Konstantin V., Buchanan, Susan K., Noinaj, Nicholas
Format: Article
Language:English
Subjects:
Bacterial Outer Membrane Proteins - chemistry
Bacterial Outer Membrane Proteins - genetics
BAM complex
BamD
BamE
cell envelope
Humans
Microbial Viability
Microbiology
Neisseria gonorrhoeae
Neisseria gonorrhoeae - chemistry
Neisseria gonorrhoeae - genetics
Protein Domains
Structure-Activity Relationship
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