Constructing protein polyhedra via orthogonal chemical interactions

Many proteins exist naturally as symmetrical homooligomers or homopolymers 1 . The emergent structural and functional properties of such protein assemblies have inspired extensive efforts in biomolecular design 2 – 5 . As synthesized by ribosomes, proteins are inherently asymmetric. Thus, they must...

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Bibliographic Details
Published in:Nature (London) 2020-02, Vol.578 (7793), p.172-176
Main Authors: Golub, Eyal, Subramanian, Rohit H., Esselborn, Julian, Alberstein, Robert G., Bailey, Jake B., Chiong, Jerika A., Yan, Xiaodong, Booth, Timothy, Baker, Timothy S., Tezcan, F. Akif
Format: Article
Language:English
Subjects:
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82/80
Amino acids
Apertures
Assemblies
BASIC BIOLOGICAL SCIENCES
Cages
Chemical interactions
Coordination Complexes - chemistry
Coordination compounds
Design
Engineers
Humanities and Social Sciences
Iron
MATERIALS SCIENCE
Metal ions
Models, Molecular
multidisciplinary
NANOSCIENCE AND NANOTECHNOLOGY
Organic chemistry
Polyhedra
Protein interaction
Proteins
Proteins - chemistry
Ribosomes
Science
Science (multidisciplinary)
Stoichiometry
Structure-function relationships
Symmetry
Zinc
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