Nanocarrier-loaded block copolymer dual domain organogels

Loaded polymer gels are prevalent materials in the controlled release community and, fairly recently, have been formulated to include nanocarrier domains such as micelles and vesicles. One mechanism used to establish the solid-like characteristic of gels is block copolymer self-assembly, which can r...

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Bibliographic Details
Published in:Polymer (Guilford) 2021-02, Vol.214 (C), p.123246, Article 123246
Main Authors: Mineart, Kenneth P., Walker, William W., Mogollon-Santiana, Joaquin, Coates, Ian A., Hong, Cameron, Lee, Byeongdu
Format: Article
Language:English
Subjects:
Block copolymers
Controlled release
Crosslinking
Domains
Gels
INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Micelles
Mineral oils
Organogels
Polymer gels
Polymers
Reverse micelles
Self-assembly
Sulfosuccinates
Ternary systems
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Summary:Loaded polymer gels are prevalent materials in the controlled release community and, fairly recently, have been formulated to include nanocarrier domains such as micelles and vesicles. One mechanism used to establish the solid-like characteristic of gels is block copolymer self-assembly, which can result in a system-spanning, physically-crosslinked network. The combination of nanocarrier and crosslink domain presence offers gels with a rich nanoscale phase space capable of intricate macroscopic property tuning. The current manuscript provides an overview of nanocarrier-loaded block copolymer organogels wherein nanocarriers are reverse micelles formed by sodium dioctyl sulfosuccinate (AOT), the block copolymer is a styrenic ABA triblock copolymer, and the gel solvent is aliphatic mineral oil. This introductory overview starts by identifying the envelope in ternary phase space wherein nanocarrier-loaded block copolymer organogels form (2–49 wt% triblock copolymer and 8x10−3-1 wt% AOT). Next, a detailed nanostructural description of gels varying in AOT and triblock copolymer concentration is presented. The manuscript concludes with demonstration of AOT reverse micelle release and gel uniaxial tensile response for gels containing 0–1 wt% AOT and 5–40 wt% styrenic triblock copolymer. [Display omitted] •Suitable formulation allows nanocarriers to be formed in block copolymer organogels.•Small angle scattering reflects nanocarrier and crosslink domain nanostructure.•Release of nanocarriers from gels is dependent on block copolymer concentration.•Gels maintain excellent mechanical properties in the presence of nanocarriers.
ISSN:0032-3861
1873-2291
DOI:10.1016/j.polymer.2020.123246