Irinotecan Loaded in Eluting Beads: Preclinical Assessment in a Rabbit VX2 Liver Tumor Model

Purpose The purpose of this study was to study the pharmacokinetics of irinotecan injected intravenously, intra-arterially, or loaded onto a delivery platform. Material and Methods Fifty-four New Zealand White rabbits with VX2 liver tumor, divided in 3 groups of 17 rabbits, each received irinotecan...

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Bibliographic Details
Published in:Cardiovascular and interventional radiology 2012-12, Vol.35 (6), p.1448-1459
Main Authors: Rao, Pramod P., Pascale, Florentina, Seck, Atman, Auperin, Anne, Drouard-Troalen, Laurence, Deschamps, Frederic, Teriitheau, Christophe, Paci, Angelo, Denys, Alban, Bize, Pierre, de Baere, Thierry
Format: Article
Language:English
Subjects:
Alanine Transaminase - blood
Animals
Antineoplastic Agents, Phytogenic - administration & dosage
Antineoplastic Agents, Phytogenic - pharmacokinetics
Aspartate Aminotransferases - blood
Bilirubin - blood
Camptothecin - administration & dosage
Camptothecin - analogs & derivatives
Camptothecin - pharmacokinetics
Cardiology
Chemoembolization, Therapeutic
Drug Delivery Systems
DRUGS
EVALUATION
Imaging
Infusions, Intra-Arterial
Infusions, Intravenous
Laboratory Investigation
LIVER
Liver Neoplasms, Experimental - drug therapy
Medicine
Medicine & Public Health
NECROSIS
NEOPLASMS
Nuclear Medicine
RABBITS
RADIOLOGY
RADIOLOGY AND NUCLEAR MEDICINE
Statistics, Nonparametric
Ultrasound
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Summary:Purpose The purpose of this study was to study the pharmacokinetics of irinotecan injected intravenously, intra-arterially, or loaded onto a delivery platform. Material and Methods Fifty-four New Zealand White rabbits with VX2 liver tumor, divided in 3 groups of 17 rabbits, each received irinotecan either by intravenous (IV) route, intra-arterial hepatic (IA) route, or loaded on drug-eluting beads (DEBIRI). Animals were killed at 1, 6, and 24 h. Irinotecan and SN-38 concentrations were measured at different time points in serum, tumor, and normal liver. Results Twelve milligrams of irinotecan were injected IV and IA, whereas 6–16.5 mg were injected loaded onto DEBIRI. Normalized serum irinotecan reached a peak of 333 ng/ml (range 198.8–502.5) for IV, 327.1 ng/ml (range 277.1–495.6) for IA, and 189.7 ng/ml (range 111.1–261.9) for DEBIRI ( P  
ISSN:0174-1551
1432-086X
DOI:10.1007/s00270-012-0343-y