Cellular membrane collapse by atmospheric-pressure plasma jet

Cellular membrane dysfunction caused by air plasma in cancer cells has been studied to exploit atmospheric-pressure plasma jets for cancer therapy. Here, we report that plasma jet treatment of cervical cancer HeLa cells increased electrical conductivity across the cellular lipid membrane and caused...

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Bibliographic Details
Published in:Applied physics letters 2014-01, Vol.104 (1)
Main Authors: Kim, Kangil, Jun Ahn, Hak, Lee, Jae-Hyeok, Kim, Jae-Ho, Sik Yang, Sang, Lee, Jong-Soo
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Air plasma
Applied physics
ATOMIC FORCE MICROSCOPY
Cancer
CELL MEMBRANES
Cellular manufacture
Collapse
ELECTRIC CONDUCTIVITY
Electrical resistivity
HELA CELLS
LIPIDS
Microelectrodes
Oxidation
Plasma
Plasma jets
Roughening
Toxicity
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Summary:Cellular membrane dysfunction caused by air plasma in cancer cells has been studied to exploit atmospheric-pressure plasma jets for cancer therapy. Here, we report that plasma jet treatment of cervical cancer HeLa cells increased electrical conductivity across the cellular lipid membrane and caused simultaneous lipid oxidation and cellular membrane collapse. We made this finding by employing a self-manufactured microelectrode chip. Furthermore, increased roughness of the cellular lipid membrane and sequential collapse of the membrane were observed by atomic force microscopy following plasma jet treatment. These results suggest that the cellular membrane catastrophe occurs via coincident altered electrical conductivity, lipid oxidation, and membrane roughening caused by an atmospheric-pressure plasma jet, possibly resulting in cellular vulnerability to reactive species generated from the plasma as well as cytotoxicity to cancer cells.
ISSN:0003-6951
1077-3118
DOI:10.1063/1.4861373