Dissipation in noisy chemical networks: The role of deficiency

We study the effect of intrinsic noise on the thermodynamic balance of complex chemical networks subtending cellular metabolism and gene regulation. A topological network property called deficiency, known to determine the possibility of complex behavior such as multistability and oscillations, is sh...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of chemical physics 2015-11, Vol.143 (18), p.184103-184103
Main Authors: Polettini, M, Wachtel, A, Esposito, M
Format: Article
Language:English
Subjects:
BALANCES
Cellular communication
CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS
CORRELATIONS
Gene expression
GENE REGULATION
METABOLISM
MOLECULES
NOISE
Organic chemistry
OSCILLATIONS
STOCHASTIC PROCESSES
THERMODYNAMICS
TOPOLOGY
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We study the effect of intrinsic noise on the thermodynamic balance of complex chemical networks subtending cellular metabolism and gene regulation. A topological network property called deficiency, known to determine the possibility of complex behavior such as multistability and oscillations, is shown to also characterize the entropic balance. In particular, when deficiency is zero the average stochastic dissipation rate equals that of the corresponding deterministic model, where correlations are disregarded. In fact, dissipation can be reduced by the effect of noise, as occurs in a toy model of metabolism that we employ to illustrate our findings. This phenomenon highlights that there is a close interplay between deficiency and the activation of new dissipative pathways at low molecule numbers.
ISSN:0021-9606
1089-7690
DOI:10.1063/1.4935064